Abstract：
Auditory processing disorder is the most common problem affecting veterans after blast exposure, but the distinct impacts of blast-related traumatic brain injury and blast-related hearing loss are unknown. Independently, both hearing loss and blast exposure affect the entire auditory processing pathway at the molecular and physiological levels. Here, we identified distinct changes to the primary auditory cortex (AI) and temporal processing in mice following blast exposure both with and without protected hearing. Our results show that blast-exposure alone activated microglia in AI, but hearing loss was required for reductions in the density of parvalbumin-expressing interneurons. Although blast exposure impaired the temporal following response, these impairments were more severe with concurrent unilateral hearing loss, further resulting in impairments in behavioral gap detection. Taken together, these results indicate that protecting hearing during blast exposure can prevent most impairments to auditory processing but does not fully protect temporal processing.
摘要：
听觉处理障碍是爆炸暴露后影响退伍军人的最常见问题，但与爆炸相关的创伤性脑损伤和与爆炸相关的听力损失的不同影响尚不清楚。独立地,听力损失和爆炸暴露都会在分子和生理水平上影响整个听觉处理途径。这里,我们确定了在有和没有受保护的听力的爆炸暴露后小鼠的主要听觉皮层(AI)和时间处理的明显变化.我们的结果表明，单独的爆炸暴露会激活AI中的小胶质细胞，但是听力损失需要降低表达小清蛋白的中间神经元的密度。尽管爆炸暴露损害了后续反应的时间，这些损伤在并发单侧听力损失时更为严重，进一步导致行为间隙检测受损。一起来看,这些结果表明，在爆炸暴露期间保护听力可以防止对听觉处理的大多数损害，但不能完全保护时间处理。
