Abstract：
Patients with CHD are less active if compared with controls and have limited functional capacity, related to muscle weakness and fatigue. The aim of this study was to evaluate the peripheral and respiratory muscle strength of children and adolescents with CHD with systematic review and meta-analysis. The review included observational and randomised control trial studies which evaluated peripheral and respiratory muscle strength in children and adolescents with CHD under 18 years old. The peripheral muscle strength was evaluated through dynamometry and respiratory muscle strength through manovacuometry. In studies that compared patients with CHD and respective control groups, it was possible to perform a meta-analysis. A total of 5634 articles met the criteria of eligibility, 15 were included in the systematic review, and 4 were included in the meta-analysis. Twelve studies assessed peripheral muscle strength with a reduction in patients with CHD. In the meta-analysis, patients with CHD had lower muscle strength than controls (-34.07 nm; 95% CI, -67.46 to -0.68; I2 47%; p for heterogeneity = 0.05), and the meta-analysis of the handgrip muscle strength showed no significant difference between patients with CHD and controls (0.08 nm; 95% CI, -6.39 to 6.55; I2 98%; p for heterogeneity <0.00001). The meta-analysis in the present study showed lower limb muscle strength in patients with CHD in comparison to controls. In contrast, no difference was found regarding hand grip strength. Also, the review showed lower respiratory muscle strength in patients with CHD, yet no meta-analysis was possible to perform.
摘要：
与对照组相比，CHD患者活动较少，功能能力有限，与肌肉无力和疲劳有关。这项研究的目的是通过系统评价和荟萃分析来评估CHD儿童和青少年的外周和呼吸肌力量。该综述包括观察性和随机对照试验研究，这些研究评估了18岁以下CHD儿童和青少年的外周和呼吸肌力量。通过动态测量法评估外周肌力，通过真空测量法评估呼吸肌力。在比较冠心病患者和相应对照组的研究中，有可能进行荟萃分析.共有5634条符合资格标准,15人被列入系统审查，和4例纳入荟萃分析。12项研究评估了冠心病患者的外周肌力降低。在荟萃分析中，冠心病患者的肌肉力量低于对照组（-34.07nm；95％CI，-67.46至-0.68；I247％；异质性p=0.05），和手握肌力的荟萃分析显示CHD患者和对照组之间没有显着差异（0.08nm;95％CI，-6.39至6.55;I298％;p为异质性<0.00001）。本研究的荟萃分析显示，与对照组相比，冠心病患者的下肢肌肉力量。相比之下,在握力方面没有发现差异。此外，该综述显示冠心病患者的呼吸肌力量较低，但无法进行荟萃分析.
