PDF(Pubmed)
Abstract：
Anillin (ANLN) is a unique scaffolding, actin-binding protein, which is essential for the integrity and ingression of the cleavage furrow. It is mainly involved in the cytokinesis process, while its role in various tumors has not been fully addressed and remains largely elusive. To provide a thorough perspective of ANLN\'s roles among diverse malignancies, we conducted a comprehensive, pan-cancer analysis about ANLN, including but not limited to gene expression levels, prognostic value, biological functions, interacting proteins, immune-related analysis, and predictive value. As a result, when compared to normal tissues, ANLN expression is elevated in most cancers, and its expression also differs in different immune subtypes and molecular subtypes in diverse cancers. In addition, in 17 types of cancer, ANLN expression is increased in early tumor stages, and higher ANLN expression predicts worse survival outcomes in more than ten cancers. Furthermore, ANLN shows close correlations with the infiltration levels of most immune cells, and enrichment analysis using ANLN co-expressed genes reveals that ANLN plays essential roles in cell cycle, mitosis, cellular senescence, and p53 signaling pathways. In the final, ANLN exhibits high accuracy in predicting many cancers, and subsequent multivariate analysis suggests ANLN could be an independent prognostic factor in specific cancer types. Taken together, ANLN is proved to be a novel and promising biomarker for its excellent predictive utility, promising prognostic value, and potential immunological roles in pan-cancer. Targeting ANLN might be an attractive approach to tumor treatment.
摘要：
Anillin（ANLN）是一种独特的脚手架，肌动蛋白结合蛋白，这对于分裂沟的完整性和侵入性至关重要。它主要参与胞质分裂过程，虽然其在各种肿瘤中的作用尚未得到充分解决，并且在很大程度上仍然难以捉摸。为了全面了解ANLN在各种恶性肿瘤中的作用，我们进行了全面的，关于ANLN的泛癌症分析，包括但不限于基因表达水平，预后价值，生物学功能,相互作用的蛋白质，免疫相关分析，和预测价值。因此,与正常组织相比，ANLN表达在大多数癌症中升高，在不同的免疫亚型和不同的癌症分子亚型中，其表达也不同。此外,在17种癌症中，ANLN表达在肿瘤早期阶段增加，更高的ANLN表达预测十多种癌症的生存结果更差。此外，ANLN与大多数免疫细胞的浸润水平密切相关，和富集分析使用ANLN共表达的基因表明，ANLN在细胞周期中发挥重要作用，有丝分裂,细胞衰老,和p53信号通路。在决赛中,ANLN在预测许多癌症方面表现出很高的准确性，随后的多变量分析提示ANLN可能是特定癌症类型的独立预后因素.一起来看,ANLN因其出色的预测效用而被证明是一种新颖且有前途的生物标志物，有希望的预后价值，以及在泛癌症中潜在的免疫学作用。靶向ANLN可能是一种有吸引力的肿瘤治疗方法。
