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Abstract：
The aim of this study was to determine the effects of menstrual cycle phases (postmenses and premenses), self-report of premenstrual syndrome (PMS), late reproductive stages (LRS1 and LRS2), and early menopausal transition (EMT) stage (Stages of Reproductive Aging Workshop [STRAW]) on severity of five symptom groups.
A subset of Seattle Midlife Women\'s Health Study participants (n = 290) in either LRS1 or LRS2 or EMT (STRAW+10 criteria) provided daily symptom data for at least one full menstrual cycle during the first year of the study and reported current PMS. Symptom severity was rated (1-4, least to most severe) in the daily diary for five symptom groups (dysphoric mood, neuromuscular, somatic, vasomotor, and insomnia) identified earlier with the same sample ( Maturitas 1996;25:1-10). A three-way analysis of variance was used to test for within- and between-participants effects on symptom severity.
Stage had no effect on severity for any of the five symptom groups. Dysphoric mood and neuromuscular and somatic symptom severity (but not vasomotor or insomnia severity) differed significantly across menstrual cycle phases, increasing from postmenses to premenses. Current PMS and premenses cycle phase had significant interactive effects on dysphoric mood and neuromuscular symptoms, but there were no significant interaction effects on somatic, vasomotor, or insomnia symptom severity.
Dysphoric mood, neuromuscular, and somatic symptoms exhibit cyclicity and are influenced by current PMS. Late reproductive stages and EMT stage do not have significant effects on the five symptom groups. Vasomotor or insomnia symptoms do not exhibit significant cyclicity from postmenses to premenses and are not affected by current PMS. Future studies of symptom cyclicity and reproductive aging including daily symptom data across an entire menstrual cycle in samples including women in late menopausal transition stage are essential to capture the effects of both cyclicity and self-reported PMS to capture symptom severity reports at their peak.
A subset of Seattle Midlife Women\'s Health Study participants (n = 290) in either LRS1 or LRS2 or EMT (STRAW+10 criteria) provided daily symptom data for at least one full menstrual cycle during the first year of the study and reported current PMS. Symptom severity was rated (1-4, least to most severe) in the daily diary for five symptom groups (dysphoric mood, neuromuscular, somatic, vasomotor, and insomnia) identified earlier with the same sample ( Maturitas 1996;25:1-10). A three-way analysis of variance was used to test for within- and between-participants effects on symptom severity.
Stage had no effect on severity for any of the five symptom groups. Dysphoric mood and neuromuscular and somatic symptom severity (but not vasomotor or insomnia severity) differed significantly across menstrual cycle phases, increasing from postmenses to premenses. Current PMS and premenses cycle phase had significant interactive effects on dysphoric mood and neuromuscular symptoms, but there were no significant interaction effects on somatic, vasomotor, or insomnia symptom severity.
Dysphoric mood, neuromuscular, and somatic symptoms exhibit cyclicity and are influenced by current PMS. Late reproductive stages and EMT stage do not have significant effects on the five symptom groups. Vasomotor or insomnia symptoms do not exhibit significant cyclicity from postmenses to premenses and are not affected by current PMS. Future studies of symptom cyclicity and reproductive aging including daily symptom data across an entire menstrual cycle in samples including women in late menopausal transition stage are essential to capture the effects of both cyclicity and self-reported PMS to capture symptom severity reports at their peak.
摘要：
这项研究的目的是确定月经周期阶段（月经后和月经前）的影响，经前期综合征（PMS）的自我报告，生殖后期（LRS1和LRS2），和早期更年期过渡（EMT）阶段（生殖衰老研讨会[STRAW]的阶段）对五个症状组的严重程度。
在LRS1或LRS2或EMT（STRAW+10标准）中，西雅图中年女性健康研究参与者的一个子集（n=290）在研究的第一年提供了至少一个完整月经周期的每日症状数据，并报告了当前的PMS。在每日日记中，对五个症状组的症状严重程度进行了评分（1-4，最不严重）（烦躁不安的情绪，神经肌肉，躯体,血管舒缩,和失眠）较早地用相同的样本确定（Maturitas1996；25：1-10）。使用三因素方差分析来测试参与者之间和参与者之间对症状严重程度的影响。
对于五个症状组中的任何一个,阶段对严重程度没有影响。情绪障碍和神经肌肉和躯体症状的严重程度（但不是血管舒缩或失眠的严重程度）在月经周期阶段显着不同，从月经后增加到月经前。当前的PMS和月经前周期阶段对烦躁不安的情绪和神经肌肉症状有显著的交互影响，但是对体细胞没有显著的交互作用,血管舒缩,或失眠症状严重。
烦躁的心情，神经肌肉，躯体症状表现出周期性，并受当前PMS的影响。生殖后期和EMT阶段对五个症状组均无明显影响。从月经后到月经前，血管舒缩或失眠症状没有明显的周期性变化，并且不受当前PMS的影响。对症状周期性和生殖衰老的未来研究，包括整个月经周期中的每日症状数据，包括绝经后期过渡阶段的女性，对于捕获周期性和自我报告的PMS的影响至关重要，以捕获症状严重程度报告。
在LRS1或LRS2或EMT（STRAW+10标准）中，西雅图中年女性健康研究参与者的一个子集（n=290）在研究的第一年提供了至少一个完整月经周期的每日症状数据，并报告了当前的PMS。在每日日记中，对五个症状组的症状严重程度进行了评分（1-4，最不严重）（烦躁不安的情绪，神经肌肉，躯体,血管舒缩,和失眠）较早地用相同的样本确定（Maturitas1996；25：1-10）。使用三因素方差分析来测试参与者之间和参与者之间对症状严重程度的影响。
对于五个症状组中的任何一个,阶段对严重程度没有影响。情绪障碍和神经肌肉和躯体症状的严重程度（但不是血管舒缩或失眠的严重程度）在月经周期阶段显着不同，从月经后增加到月经前。当前的PMS和月经前周期阶段对烦躁不安的情绪和神经肌肉症状有显著的交互影响，但是对体细胞没有显著的交互作用,血管舒缩,或失眠症状严重。
烦躁的心情，神经肌肉，躯体症状表现出周期性，并受当前PMS的影响。生殖后期和EMT阶段对五个症状组均无明显影响。从月经后到月经前，血管舒缩或失眠症状没有明显的周期性变化，并且不受当前PMS的影响。对症状周期性和生殖衰老的未来研究，包括整个月经周期中的每日症状数据，包括绝经后期过渡阶段的女性，对于捕获周期性和自我报告的PMS的影响至关重要，以捕获症状严重程度报告。
