PDF(Pubmed)
Abstract：
Coronavirus disease 2019 is a highly contagious respiratory disease caused by severe acute respiratory syndrome coronavirus 2. This disease as well as its various treatments like steroids, antivirals, and antibacterials can alter the immune state of the affected individuals and result in secondary infections such as mucormycosis. Mucormycosis is a well-known opportunistic fungal infection that affects immunocompromised subjects, particularly those with diabetes mellitus, prolonged antibiotic or steroid use, and patients with organ trans-plantation, neutropenia, and hematological malignancies. Rhino-orbital-cerebral mucormycosis is an aggressive disease owing to its ability to invade the blood vessels by fungal hyphae, leading to necrosis of the involved structures. Large cases were reported from India, indicating that this clinical entity shows a geographical variation. The affected patients are suffering on a clinical spectrum depending on the stage of the disease. Radiological assessment, including computerized tomography and magnetic resonance imaging, is necessary to evaluate the stage of the disease and choose the appropriate surgical treatment. A multidisciplinary approach is required to treat rhino-orbital-cerebral mucor-mycosis and includes local or intravenous antifungal drugs, debridement of the dead tissues, and appropriate management of any predisposing conditions. The disease has a very poor prognosis with a death rate of 50%. This review aimed to sum-marize the demographic and clinical risk factors, investigations, treatments, and outcomes of coronavirus disease 2019 patients with rhino-orbital-cerebral mucormycosis.
摘要：
2019年冠状病毒病是由严重急性呼吸道综合征冠状病毒2引起的高度传染性呼吸道疾病。这种疾病以及类固醇等各种治疗方法，抗病毒药物,和抗菌药物可以改变受影响个体的免疫状态，并导致继发感染，如毛霉菌病。毛霉菌病是一种众所周知的机会性真菌感染，会影响免疫功能低下的受试者，尤其是糖尿病患者，长期使用抗生素或类固醇，和器官移植的病人，中性粒细胞减少症,和血液恶性肿瘤。犀牛-眶-脑毛霉菌病是一种侵袭性疾病，由于其能够通过真菌菌丝侵入血管，导致相关结构坏死。印度报告了大量病例，表明该临床实体显示出地理差异。受影响的患者根据疾病的阶段而在临床范围内遭受痛苦。放射学评估,包括计算机断层扫描和磁共振成像，有必要评估疾病的阶段并选择合适的手术治疗方法。需要多学科方法来治疗鼻-眶-脑黏液-真菌病，包括局部或静脉注射抗真菌药物，对死亡组织进行清创术,以及对任何易感条件的适当管理。该疾病的预后很差，死亡率为50％。这篇综述旨在总结人口统计学和临床危险因素，调查,治疗,2019年冠状病毒病伴鼻-眶-脑毛霉菌病患者的结局。
