PDF(Pubmed)
Abstract：
Estrogens can alter the biology of various tissues and organs, including the brain, and thus play an essential role in modulating homeostasis. Despite its traditional role in reproduction, it is now accepted that estrogen and its analogues can exert neuroprotective effects. Several studies have shown the beneficial effects of estrogen in ameliorating and delaying the progression of neurodegenerative diseases, including Alzheimer\'s and Parkinson\'s disease and various forms of brain injury disorders. While the classical effects of estrogen through intracellular receptors are more established, the impact of the non-classical pathway through receptors located at the plasma membrane as well as the rapid stimulation of intracellular signaling cascades are still under active research. Moreover, it has been suggested that the non-classical estrogen pathway plays a crucial role in neuroprotection in various brain areas. In this mini-review, we will discuss the use of compounds targeting the non-classical estrogen pathway in their potential use as treatment in neurodegenerative diseases and brain injury disorders.
摘要：
雌激素可以改变各种组织和器官的生物学，包括大脑,因此在调节体内平衡中起着至关重要的作用。尽管它在繁殖中的传统作用，现在人们普遍认为雌激素及其类似物可以发挥神经保护作用。一些研究表明，雌激素在改善和延缓神经退行性疾病的进展方面具有有益的作用，包括阿尔茨海默病和帕金森病以及各种形式的脑损伤疾病。虽然雌激素通过细胞内受体的经典作用更为成熟，通过位于质膜的受体的非经典途径的影响以及细胞内信号级联的快速刺激仍在积极研究中。此外，有人认为，非经典雌激素途径在不同脑区的神经保护中起着至关重要的作用。在这个小型审查中，我们将讨论靶向非经典雌激素途径的化合物在治疗神经退行性疾病和脑损伤疾病中的潜在用途。
