Abstract：
Autoimmune thyroid disease has been described as a complication of HSCT for different indications and as a manifestation of inborn errors of immunity, like SCID. A 1-month female was diagnosed with RAG1-mutated SCID and received allogenic HSCT. She developed autoimmune hypothyroidism 5 months after transplantation and was treated with levo-thyroxine with a good response. Autoimmune thyroid disease can develop after HSCT during the immune reconstitution phase, leading to potentially severe neurological and growth impairment, particularly in SCID patients, often transplanted during the first year of life. Recommendations regarding early and frequent vigilance for thyroid function are needed in these patients.
摘要：
自身免疫性甲状腺疾病已被描述为HSCT的并发症，用于不同的适应症和先天性免疫错误的表现。比如SCID.一名1个月的女性被诊断为RAG1突变的SCID，并接受了同种异体HSCT。移植后5个月，她出现了自身免疫性甲状腺功能减退症，并接受了左旋甲状腺素治疗，反应良好。自身免疫性甲状腺疾病可在免疫重建阶段HSCT后发展，导致潜在的严重神经和生长障碍，特别是在SCID患者中，经常在生命的第一年移植。这些患者需要早期和经常警惕甲状腺功能的建议。
