Pemphigus vulgaris with refractory gingival ulcerations, successfully treated with rituximab-A case report.

寻常型天疱疮伴难治性牙龈溃疡 ，成功治疗利妥昔单抗 - 1 例报告。

• 发表时间: Sep 2022
• 来源期刊: Clin Case Rep
• DOI: 10.1002/ccr3.6321
• PMID: 36177086
• 文章类型: Case Reports
• 作者列表: Dolenc-Voljč M,Povšič K,Kučič AC,Gašperšič R,Dolenc-Voljč M,Povšič K,Kučič AC,Gašperšič R

关键词: desquamative gingivitis; gingiva; pemphigus vulgaris; rituximab; ulceration; desquamative gingivitis; gingiva; pemphigus vulgaris; rituximab; ulceration

Abstract

A patient presented with ulcerations of the buccal mucosae, palate and gingiva. A gingival biopsy confirmed the diagnosis as pemphigus vulgaris. Despite medication with systemic corticosteroids and mycophenolate mofetil, desquamative gingivitis persisted. Adjunct treatment with rituximab was therefore introduced. Regular follow-ups revealed no inflammatory gingival changes even 6 years later.

摘要

一名患者出现颊粘膜溃疡，腭和牙龈。牙龈活检证实诊断为寻常型天疱疮。尽管药物使用全身性皮质类固醇和霉酚酸酯，脱皮性牙龈炎持续存在。因此引入了利妥昔单抗的辅助治疗。定期随访显示即使6年后也没有炎症性牙龈变化。