Abstract：
Intestinal microbiota is symbiotically associated with host health, learning about the characteristics of microbiota and the factors that modulate it could assist in developing strategies to promote human health and prevent diseases. Polysaccharides from Lycium barbarum (LBPs) are found beneficial for enhancing the activity of gut microbiota, as a potential prebiotic, which not only participates in improving body immunity, obesity, hyperlipidemia and systemic inflammation induced by oxidative stress, but also plays a magnificent role in regulating intestinal microenvironment and improving host health and target intestinal effects via its biological activities, as well as gut microbiota and metabolites. To highlight the internal relationship between intestinal microbiota and LBPs, this review focuses on the latest advances in LBPs on the intestinal microbiota, metabolites, immune regulation, intestinal barrier protection, microbiota-gut-brain axis and host health. Moreover, the preparation, structure, bioactivity and modification of LBPs were also discussed. This review may offer new perspective on LBPs improving health of gut and host via intestinal microbiota, and provide useful guidelines for the application of LBPs in the food industry.
摘要：
肠道微生物群与宿主健康共生相关，了解微生物群的特征及其调节因素有助于制定促进人类健康和预防疾病的策略。枸杞多糖（LBP）被发现有利于增强肠道微生物群的活性，作为一种潜在的益生元，它不仅参与提高身体免疫力，肥胖，氧化应激引起的高脂血症和全身性炎症，而且通过其生物活性在调节肠道微环境、改善宿主健康和靶向肠道效应方面发挥着巨大作用，以及肠道微生物群和代谢产物。为了强调肠道菌群与LBP之间的内在联系，这篇综述集中在LBP对肠道微生物群的最新进展，代谢物，免疫调节，肠道屏障保护，微生物群-肠-脑轴与宿主健康。此外，准备,结构,还讨论了LBP的生物活性和修饰。这篇综述可能为LBP通过肠道菌群改善肠道和宿主健康提供新的视角。并为LBP在食品工业中的应用提供有用的指南。
