Abstract：
Embryonic stem cells give rise to teratomas when injected in vivo in experimental animal models. The characterization, the manipulation, and the breaking off of this specific characteristic are doubtlessly the last frontier for the applications of stem cells in translational medicine. Moreover, the urgency to adapt to new scientific demands drives the researcher to find alternative and faster models for testing the teratogenic properties of embryonic stem cells. Here, we compare the emerging model of the chick embryo chorioallantoic membrane (CAM) to the murine model, which represents the gold standard procedure for teratogenesis.
摘要：
胚胎干细胞在实验动物模型体内注射时会产生畸胎瘤。表征，操纵，而打破这一特定特征无疑是干细胞在转化医学中应用的最后前沿。此外，适应新的科学需求的紧迫性促使研究人员寻找替代和更快的模型来测试胚胎干细胞的致畸特性。这里,我们将鸡胚绒毛尿囊膜（CAM）的新兴模型与小鼠模型进行了比较，这代表了畸形发生的黄金标准程序。
