PDF(Pubmed)
Abstract：
While the incidence of gastric cancer (GC) in general has decreased worldwide in recent decades, the incidence of diffuse cancer historically comprising poorly cohesive cells-GC (PCC-GC) and including signet ring cell cancer is rising. Literature concerning PCC-GC is scarce and unclear, mostly due to a large variety of historically used definitions and classifications. Compared to other histological subtypes of GC, PCC-GC is nevertheless characterized by a distinct set of epidemiological, histological and clinical features which require a specific diagnostic and therapeutic approach. The aim of this review was to provide an update on the definition, classification and therapeutic strategies of PCC-GC. We focus on the updated histological definition of PCC-GC, along with its implications on future treatment strategies and study design. Also, specific considerations in the diagnostic management are discussed. Finally, the impact of some recent developments in the therapeutic management of GC in general such as the recently validated taxane-based regimens (5-Fluorouracil, leucovorin, oxaliplatin and docetaxel), the use of hyperthermic intraperitoneal chemotherapy as well as pressurized intraperitoneal aerosol chemotherapy and targeted therapy have been reviewed in depth for their relative importance for PCC-GC in particular.
摘要：
尽管近几十年来，胃癌（GC）的发病率在全球范围内总体上有所下降，从历史上看,弥漫性癌症的发病率正在上升,其中包括内聚性细胞-GC(PCC-GC)和印戒细胞癌.关于PCC-GC的文献很少，也不清楚，主要是由于历史上使用的定义和分类种类繁多。与GC的其他组织学亚型相比，然而，PCC-GC的特点是一组独特的流行病学，需要特定诊断和治疗方法的组织学和临床特征。这次审查的目的是提供最新的定义，PCC-GC的分类和治疗策略。我们专注于PCC-GC的最新组织学定义，以及它对未来治疗策略和研究设计的影响。此外，讨论了诊断管理中的具体考虑因素。最后,一般GC治疗管理的一些最新进展的影响，例如最近验证的基于紫杉烷的方案（5-氟尿嘧啶，亚叶酸,奥沙利铂和多西他赛），对于腹腔热化疗以及腹腔加压气雾剂化疗和靶向治疗的使用,我们已经对它们在PCC-GC中的相对重要性进行了深入的综述.
