PDF(Pubmed)
Abstract：
Differential diagnosis of neuropsychiatric symptoms in a patient with an underlying malignancy is exhaustive. 5-fluorouracil (5-FU) is one of the most widely used chemotherapy agents and it is often used as the first-line regimen in head and neck malignancies. We present a case of an elderly female with an underlying locally advanced p16-positive squamous cell carcinoma of the tongue who presented with manic symptoms for one week after cycle 2 of chemotherapy. Multidisciplinary management by otorhinolaryngologists with psychiatrist and oncologist led to the cessation of 5-FU, administration of antipsychotics, and replacement with a different chemotherapy agent, leading to complete resolution of manic symptoms. Possible mechanisms of the 5-FU-induced manic episode with its treatment are discussed in this report.
摘要：
患有潜在恶性肿瘤的患者的神经精神症状的鉴别诊断是详尽的。5-氟尿嘧啶（5-FU）是最广泛使用的化疗药物之一，通常用作头颈部恶性肿瘤的一线治疗方案。我们介绍了一例老年女性，患有潜在的局部晚期p16阳性舌鳞状细胞癌，在化疗第2周期后一周出现躁狂症状。耳鼻喉科医师与精神病医生和肿瘤学家的多学科管理导致5-FU停止，抗精神病药的管理，用不同的化疗药物代替，导致躁狂症状完全缓解。本报告讨论了5-FU诱导的躁狂发作及其治疗的可能机制。
