关键词: de-labelling drug provocation testing healthcare professional penicillin allergy risk stratification

Mesh : Adult Anti-Bacterial Agents / adverse effects Child Drug Hypersensitivity / diagnosis epidemiology therapy Hospitals Humans Penicillins / adverse effects beta-Lactams / adverse effects

来  源:   DOI:10.1111/cea.14217

Abstract:
The Standards of Care Committee of the British Society for Allergy and Clinical Immunology (BSACI) and a committee of experts and key stakeholders have developed this guideline for the evaluation and testing of patients with an unsubstantiated label of penicillin allergy. The guideline is intended for UK clinicians who are not trained in allergy or immunology, but who wish to develop a penicillin allergy de-labelling service for their patients. It is intended to supplement the BSACI 2015 guideline \"Management of allergy to penicillin and other beta-lactams\" and therefore does not detail the epidemiology or aetiology of penicillin allergy, as this is covered extensively in the 2015 guideline (1). The guideline is intended for use only in patients with a label of penicillin allergy and does not apply to other beta-lactam allergies. The recommendations include a checklist to identify patients at low risk of allergy and a framework for the conduct of drug provocation testing by non-allergists. There are separate sections for adults and paediatrics within the guideline, in recognition of the common differences in reported allergy history and likelihood of true allergy.
摘要:
英国过敏和临床免疫学协会(BSACI)的护理标准委员会以及专家和主要利益相关者委员会已经制定了该指南,用于评估和测试未经证实的青霉素过敏标签的患者。该指南适用于未经过敏或免疫学培训的英国临床医生,但他们希望为患者开发青霉素过敏去标签服务。它旨在补充BSACI2015指南“青霉素和其他β-内酰胺过敏的管理”,因此没有详细说明青霉素过敏的流行病学或病因。因为这在2015年指南(1)中被广泛涵盖。该指南仅适用于具有青霉素过敏标签的患者,不适用于其他β-内酰胺过敏。这些建议包括一份清单,以识别过敏风险较低的患者,以及一个由非过敏专家进行药物激发试验的框架。指南中有成人和儿科的单独部分,认识到报告的过敏史和真正过敏可能性的共同差异。
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