Abstract：
Besides the broad development of nanotechnological approaches for cancer diagnosis and therapy, currently, there is no significant progress in the treatment of different types of brain tumors. Therapeutic molecules crossing the blood-brain barrier (BBB) and reaching an appropriate targeting ability remain the key challenges. Many invasive and non-invasive methods, and various types of nanocarriers and their hybrids have been widely explored for brain tumor treatment. However, unfortunately, no crucial clinical translations were observed to date. In particular, chemotherapy and surgery remain the main methods for the therapy of brain tumors. Exploring the mechanisms of the BBB penetration in detail and investigating advanced drug delivery platforms are the key factors that could bring us closer to understanding the development of effective therapy against brain tumors. In this review, we discuss the most relevant aspects of the BBB penetration mechanisms, observing both invasive and non-invasive methods of drug delivery. We also review the recent progress in the development of functional drug delivery platforms, from viruses to cell-based vehicles, for brain tumor therapy. The destructive potential of chemotherapeutic drugs delivered to the brain tumor is also considered. This review then summarizes the existing challenges and future prospects in the use of drug delivery platforms for the treatment of brain tumors.
摘要：
除了用于癌症诊断和治疗的纳米技术方法的广泛发展之外，目前,不同类型脑肿瘤的治疗无明显进展。穿过血脑屏障（BBB）并达到适当的靶向能力的治疗分子仍然是关键挑战。许多侵入性和非侵入性方法，各种类型的纳米载体及其杂种已被广泛用于脑肿瘤治疗。然而,不幸的是,迄今为止没有观察到重要的临床翻译.特别是,化疗和手术仍然是治疗脑肿瘤的主要方法。详细探索BBB渗透的机制和研究先进的药物递送平台是使我们更接近了解针对脑肿瘤的有效疗法发展的关键因素。在这次审查中,我们讨论了BBB渗透机制的最相关方面，观察药物递送的侵入性和非侵入性方法。我们还回顾了功能药物输送平台的最新进展，从病毒到细胞载体，用于脑肿瘤治疗。还考虑了递送到脑肿瘤的化疗药物的破坏性潜力。然后，本文总结了使用药物递送平台治疗脑肿瘤的现有挑战和未来前景。
