Abstract：
OBJECTIVE: The objective of this study was to determine if hemodialysis patients who have undergone an invasive dental treatment are at risk of developing infective endocarditis.
METHODS: This study was a cohort case-control design and used secondary data collected from the National Health Insurance Research Database of Taiwan. The case group and the control group were each comprised of 19,602 hemodialysis patients. The control group was matched for four variables: age, gender, a medical history of diabetes mellitus, and a cerebrovascular event. After matching, the case group and the control group were each comprised of 19,602 hemodialysis patients. Cox regression analysis determined hazard ratios and 95% confidence intervals.
RESULTS: Patients were followed up at 1 month and 3 months after receiving invasive dental treatment. The results showed the cohort case-control hazard ratio was 0.88 (95% CI, 0.49, 1.57) 1 month after receiving invasive dental treatment. Three months after receiving IDT, the cohort case-control hazard ratio was 1.04 (95% CI, 0.71, 1.52). Hazard ratios did not differ significantly between groups.
CONCLUSIONS: Hemodialysis patients who received invasive dental treatment had no greater risk of developing infective endocarditis than matched control patients. The results of this study should alleviate concerns for hemodialysis patients and dentists about invasive dental treatment procedures. We recommend hemodialysis patients undergo invasive dental treatment when needed.
CONCLUSIONS: The results of this study showed that invasive dental treatment did not increase their risk of developing infective endocarditis. Hemodialysis patients in need of an invasive dental procedure should be encouraged to undergo treatment if the dentist deems it necessary.
METHODS: This study was a cohort case-control design and used secondary data collected from the National Health Insurance Research Database of Taiwan. The case group and the control group were each comprised of 19,602 hemodialysis patients. The control group was matched for four variables: age, gender, a medical history of diabetes mellitus, and a cerebrovascular event. After matching, the case group and the control group were each comprised of 19,602 hemodialysis patients. Cox regression analysis determined hazard ratios and 95% confidence intervals.
RESULTS: Patients were followed up at 1 month and 3 months after receiving invasive dental treatment. The results showed the cohort case-control hazard ratio was 0.88 (95% CI, 0.49, 1.57) 1 month after receiving invasive dental treatment. Three months after receiving IDT, the cohort case-control hazard ratio was 1.04 (95% CI, 0.71, 1.52). Hazard ratios did not differ significantly between groups.
CONCLUSIONS: Hemodialysis patients who received invasive dental treatment had no greater risk of developing infective endocarditis than matched control patients. The results of this study should alleviate concerns for hemodialysis patients and dentists about invasive dental treatment procedures. We recommend hemodialysis patients undergo invasive dental treatment when needed.
CONCLUSIONS: The results of this study showed that invasive dental treatment did not increase their risk of developing infective endocarditis. Hemodialysis patients in need of an invasive dental procedure should be encouraged to undergo treatment if the dentist deems it necessary.
摘要：
目的：本研究的目的是确定接受侵入性牙科治疗的血液透析患者是否有发生感染性心内膜炎的风险。
方法：本研究是一项队列病例对照设计，使用从台湾国家健康保险研究数据库收集的二级数据。病例组和对照组各19,602例血液透析患者。对照组匹配四个变量：年龄，性别,糖尿病病史,和脑血管事件。匹配后,病例组和对照组各包括19,602例血液透析患者.Cox回归分析确定了风险比和95%置信区间。
结果：患者接受侵入性牙科治疗后1个月和3个月随访。结果显示，在接受侵入性牙科治疗1个月后，队列病例对照风险比为0.88（95％CI，0.49，1.57）。收到IDT三个月后，队列病例对照风险比为1.04(95%CI,0.71,1.52).两组之间的危险比没有显着差异。
结论：接受侵入性牙科治疗的血液透析患者发生感染性心内膜炎的风险没有高于对照组患者。这项研究的结果应减轻血液透析患者和牙医对侵入性牙科治疗程序的担忧。我们建议血液透析患者在需要时接受侵入性牙科治疗。
结论：这项研究的结果表明，侵入性牙科治疗并没有增加其发生感染性心内膜炎的风险。如果牙医认为有必要，应鼓励需要侵入性牙科手术的血液透析患者接受治疗。
方法：本研究是一项队列病例对照设计，使用从台湾国家健康保险研究数据库收集的二级数据。病例组和对照组各19,602例血液透析患者。对照组匹配四个变量：年龄，性别,糖尿病病史,和脑血管事件。匹配后,病例组和对照组各包括19,602例血液透析患者.Cox回归分析确定了风险比和95%置信区间。
结果：患者接受侵入性牙科治疗后1个月和3个月随访。结果显示，在接受侵入性牙科治疗1个月后，队列病例对照风险比为0.88（95％CI，0.49，1.57）。收到IDT三个月后，队列病例对照风险比为1.04(95%CI,0.71,1.52).两组之间的危险比没有显着差异。
结论：接受侵入性牙科治疗的血液透析患者发生感染性心内膜炎的风险没有高于对照组患者。这项研究的结果应减轻血液透析患者和牙医对侵入性牙科治疗程序的担忧。我们建议血液透析患者在需要时接受侵入性牙科治疗。
结论：这项研究的结果表明，侵入性牙科治疗并没有增加其发生感染性心内膜炎的风险。如果牙医认为有必要，应鼓励需要侵入性牙科手术的血液透析患者接受治疗。
