The ethical case for placebo control in HIV-cure-related studies with ART interruption.

在 ART 中断的 HIV 治愈相关研究中 ， 安慰剂对照的伦理案例。

• 影响指数: 5.148
• 发表时间: Sep 2022
• 来源期刊: J Virus Erad
• DOI: 10.1016/j.jve.2022.100084
• PMID: 36106155
• 文章类型: Journal Article
• 作者列表: Magalhaes M,Kuritzkes DR,Eyal N,Magalhaes M,Kuritzkes DR,Eyal N

关键词: Analytic treatment interruption; HIV Cure-related studies; Human subjects research; Placebos; Research ethics; Analytic treatment interruption; HIV Cure-related studies; Human subjects research; Placebos; Research ethics

Abstract

Many studies that seek to cure HIV must ask participants to interrupt their antiretroviral treatment. In such circumstances, is it permissible to include a placebo group in the study? We explain why doing so is a scientific and an ethical necessity, and more benign than imagined.

摘要

许多寻求治愈艾滋病毒的研究必须要求参与者中断其抗逆转录病毒治疗。在这种情况下,是否允许在研究中加入安慰剂组？我们解释了为什么这样做是科学和道德上的必要性，比想象中更良性。