PDF(Pubmed)
Abstract：
UNASSIGNED: Sarcopenia is a new and emerging risk factor aggravating the quality of life of elderly population. Because Korean Red Ginseng (RG) is known to have a great effect on relieving fatigue and enhancing physical performance, it is invaluable to examine its potential as an anti-sarcopenic drug.
UNASSIGNED: Anti-sarcopenic effect of non-saponin fraction of Korean Red Ginseng (RGNS) was evaluated in C2C12 myoblasts treated with C2-ceramide to induce senescence phenotypes, and 22-month-old mice fed with chow diet containing 2% RGNS (w/w) for 4 further months.
UNASSIGNED: The RGNS treatment significantly alleviated cellular senescence indicated by intracellular lipid accumulation, increased amount of lysosomal β-galactosidase, and reduced proliferative capacity in C2C12 myoblasts. This effect was not observed with saponin fraction. In an aged mouse, the 4-month-RGNS diet significantly improved aging-associated loss of muscle mass and strength, assessed by the weights of hindlimb skeletal muscles such as tibialis anterior (TA), extensor digitorum longus (EDL), gastrocnemius (GN) and soleus (SOL), and the cross-sectional area (CSA) of SOL muscle, and the behaviors in grip strength and hanging wire tests, respectively. During the same period, an aging-associated shift of fast-to slow-twitch muscle in SOL muscle was also retarded by the RGNS treatment.
UNASSIGNED: These findings suggested that the long-term diet of RGNS significantly prevented aging-associated muscle atrophy and reduced physical performance, and thus RGNS has a strong potential to be developed as a drug that prevents or improves sarcopenia.
UNASSIGNED: Anti-sarcopenic effect of non-saponin fraction of Korean Red Ginseng (RGNS) was evaluated in C2C12 myoblasts treated with C2-ceramide to induce senescence phenotypes, and 22-month-old mice fed with chow diet containing 2% RGNS (w/w) for 4 further months.
UNASSIGNED: The RGNS treatment significantly alleviated cellular senescence indicated by intracellular lipid accumulation, increased amount of lysosomal β-galactosidase, and reduced proliferative capacity in C2C12 myoblasts. This effect was not observed with saponin fraction. In an aged mouse, the 4-month-RGNS diet significantly improved aging-associated loss of muscle mass and strength, assessed by the weights of hindlimb skeletal muscles such as tibialis anterior (TA), extensor digitorum longus (EDL), gastrocnemius (GN) and soleus (SOL), and the cross-sectional area (CSA) of SOL muscle, and the behaviors in grip strength and hanging wire tests, respectively. During the same period, an aging-associated shift of fast-to slow-twitch muscle in SOL muscle was also retarded by the RGNS treatment.
UNASSIGNED: These findings suggested that the long-term diet of RGNS significantly prevented aging-associated muscle atrophy and reduced physical performance, and thus RGNS has a strong potential to be developed as a drug that prevents or improves sarcopenia.
摘要：
UNASSIGNED：肌肉减少症是一种新出现的危险因素，会加重老年人群的生活质量。因为众所周知，韩国红参(RG)对缓解疲劳和提高身体机能有很大的作用，研究其作为抗肌肉节制药物的潜力是非常宝贵的。
UNASSIGNED：在用C2-神经酰胺处理的C2C12成肌细胞中评估了韩国红参非皂苷部分（RGNS）的抗肌肉节制作用，以诱导衰老表型，和用含有2％RGNS（w/w）的食物饮食喂养的22月龄小鼠再吃4个月。
未经证实：RGNS治疗可显着减轻细胞内脂质积累所指示的细胞衰老，溶酶体β-半乳糖苷酶的增加，C2C12成肌细胞的增殖能力降低。使用皂苷部分没有观察到这种效果。在一只年老的老鼠身上，4个月的RGNS饮食显着改善了与衰老相关的肌肉质量和力量损失，通过后肢骨骼肌的重量评估，如胫骨前肌（TA），趾长伸肌（EDL），腓肠肌（GN）和比目鱼（SOL），和SOL肌肉的横截面积(CSA)，以及握力和悬挂线测试中的行为，分别。在同一时期,RGNS治疗也延缓了SOL肌肉中与衰老相关的快速抽搐到缓慢抽搐的转变。
UNASSIGNED：这些发现表明，RGNS的长期饮食可显着预防与衰老相关的肌肉萎缩和身体表现下降，因此，RGNS具有被开发为预防或改善肌肉减少症的药物的强大潜力。
UNASSIGNED：在用C2-神经酰胺处理的C2C12成肌细胞中评估了韩国红参非皂苷部分（RGNS）的抗肌肉节制作用，以诱导衰老表型，和用含有2％RGNS（w/w）的食物饮食喂养的22月龄小鼠再吃4个月。
未经证实：RGNS治疗可显着减轻细胞内脂质积累所指示的细胞衰老，溶酶体β-半乳糖苷酶的增加，C2C12成肌细胞的增殖能力降低。使用皂苷部分没有观察到这种效果。在一只年老的老鼠身上，4个月的RGNS饮食显着改善了与衰老相关的肌肉质量和力量损失，通过后肢骨骼肌的重量评估，如胫骨前肌（TA），趾长伸肌（EDL），腓肠肌（GN）和比目鱼（SOL），和SOL肌肉的横截面积(CSA)，以及握力和悬挂线测试中的行为，分别。在同一时期,RGNS治疗也延缓了SOL肌肉中与衰老相关的快速抽搐到缓慢抽搐的转变。
UNASSIGNED：这些发现表明，RGNS的长期饮食可显着预防与衰老相关的肌肉萎缩和身体表现下降，因此，RGNS具有被开发为预防或改善肌肉减少症的药物的强大潜力。
