PDF(Pubmed)
Abstract：
UNASSIGNED: Concurrent chemoradiotherapy (CCRT)-induced oral mucositis (OM) causes oral pain, malnutrition, and impaired quality of life in patients with head and neck cancer (HNC). Phytochemicals play a potential role in eliminating cancer therapy toxicity.
UNASSIGNED: To evaluate the effect of phytochemical-rich vegetable and fruit juice (VFJ) consumption in preventing CCRT-induced OM among patients with locally advanced HNC.
UNASSIGNED: Forty-nine patients with HNC undergoing CCRT were enrolled. All patients received nutritional counseling before CCRT and weekly follow-up. The VFJ group (25 patients) received 600 mL/day VFJ, 5 days/week for two weeks preceding CCRT and during CCRT, and the control group (24 patients) did not. The contents of total polyphenols and carotenoids in the VFJ were determined. Changes in anthropometric, dietary, and laboratory profiles were compared. Assessment of OM was based on the World Health Organization (WHO) scoring system.
UNASSIGNED: Total polyphenols content was 64.6 mg gallic acid equivalents per 100 mL of the VFJ, and the main carotenoids were β-carotene and lycopene. The mean daily consumption of the VFJ was 538 mL for VFJ group. Changes in body weight, albumin, and energy intake were not significantly different between the two groups. The incidence of ulcerative OM was significantly lower in VFJ (64.0%) than in control (95.8%) subjects at week 6 of CCRT. Multiple logistic regressions revealed that VFJ consumption correlated significantly with lower risks of ulcerative OM.
UNASSIGNED: Consumption of VFJ rich in phytochemicals including total polyphenols and carotenoids effectively alleviates the severity of CCRT-induced OM among patients with locally advanced HNC.
UNASSIGNED: Preventive Medicine; Dietary Therapy/Nutrition Supplements.
UNASSIGNED: (classification by EVISE)Preventive medicine, dietary therapy, nutrition supplements.
UNASSIGNED: To evaluate the effect of phytochemical-rich vegetable and fruit juice (VFJ) consumption in preventing CCRT-induced OM among patients with locally advanced HNC.
UNASSIGNED: Forty-nine patients with HNC undergoing CCRT were enrolled. All patients received nutritional counseling before CCRT and weekly follow-up. The VFJ group (25 patients) received 600 mL/day VFJ, 5 days/week for two weeks preceding CCRT and during CCRT, and the control group (24 patients) did not. The contents of total polyphenols and carotenoids in the VFJ were determined. Changes in anthropometric, dietary, and laboratory profiles were compared. Assessment of OM was based on the World Health Organization (WHO) scoring system.
UNASSIGNED: Total polyphenols content was 64.6 mg gallic acid equivalents per 100 mL of the VFJ, and the main carotenoids were β-carotene and lycopene. The mean daily consumption of the VFJ was 538 mL for VFJ group. Changes in body weight, albumin, and energy intake were not significantly different between the two groups. The incidence of ulcerative OM was significantly lower in VFJ (64.0%) than in control (95.8%) subjects at week 6 of CCRT. Multiple logistic regressions revealed that VFJ consumption correlated significantly with lower risks of ulcerative OM.
UNASSIGNED: Consumption of VFJ rich in phytochemicals including total polyphenols and carotenoids effectively alleviates the severity of CCRT-induced OM among patients with locally advanced HNC.
UNASSIGNED: Preventive Medicine; Dietary Therapy/Nutrition Supplements.
UNASSIGNED: (classification by EVISE)Preventive medicine, dietary therapy, nutrition supplements.
摘要：
未经证实：同步放化疗（CCRT）引起的口腔黏膜炎（OM）引起口腔疼痛，营养不良,头颈癌（HNC）患者的生活质量受损。植物化学物质在消除癌症治疗毒性中起着潜在的作用。
UNASSIGNED：评估富含植物化学物质的蔬菜汁（VFJ）在预防局部晚期HNC患者中CCRT诱导的OM中的作用。
UNASSIGNED：纳入49例接受CCRT的HNC患者。所有患者在CCRT前接受营养咨询，每周随访。VFJ组（25例）接受600mL/天的VFJ，在CCRT之前和CCRT期间，每周5天，持续两周，对照组（24例）没有。测定了VFJ中总多酚和类胡萝卜素的含量。人体测量学的变化,饮食，和实验室概况进行了比较。OM的评估基于世界卫生组织（WHO）评分系统。
未经证实：总多酚含量为每100mLVFJ64.6mg没食子酸当量，类胡萝卜素主要为β-胡萝卜素和番茄红素。VFJ组的VFJ的平均每日消耗量为538mL。体重的变化,白蛋白,两组之间的能量摄入没有显着差异。在CCRT的第6周，VFJ（64.0％）的溃疡性OM发生率显着低于对照组（95.8％）。多重Logistic回归显示，VFJ消耗与溃疡性OM的风险降低显着相关。
UNASSIGNED：食用富含植物化学物质（包括总多酚和类胡萝卜素）的VFJ可有效缓解局部晚期HNC患者中CCRT诱导的OM的严重程度。
未经批准：预防医学；膳食治疗/营养补充剂。
未经评估：（按EVISE分类）预防医学，饮食疗法，营养补充剂。
UNASSIGNED：评估富含植物化学物质的蔬菜汁（VFJ）在预防局部晚期HNC患者中CCRT诱导的OM中的作用。
UNASSIGNED：纳入49例接受CCRT的HNC患者。所有患者在CCRT前接受营养咨询，每周随访。VFJ组（25例）接受600mL/天的VFJ，在CCRT之前和CCRT期间，每周5天，持续两周，对照组（24例）没有。测定了VFJ中总多酚和类胡萝卜素的含量。人体测量学的变化,饮食，和实验室概况进行了比较。OM的评估基于世界卫生组织（WHO）评分系统。
未经证实：总多酚含量为每100mLVFJ64.6mg没食子酸当量，类胡萝卜素主要为β-胡萝卜素和番茄红素。VFJ组的VFJ的平均每日消耗量为538mL。体重的变化,白蛋白,两组之间的能量摄入没有显着差异。在CCRT的第6周，VFJ（64.0％）的溃疡性OM发生率显着低于对照组（95.8％）。多重Logistic回归显示，VFJ消耗与溃疡性OM的风险降低显着相关。
UNASSIGNED：食用富含植物化学物质（包括总多酚和类胡萝卜素）的VFJ可有效缓解局部晚期HNC患者中CCRT诱导的OM的严重程度。
未经批准：预防医学；膳食治疗/营养补充剂。
未经评估：（按EVISE分类）预防医学，饮食疗法，营养补充剂。
