Abstract：
This study aimed to describe neurodevelopment in fetal growth restriction children at the age of six. Secondly, we tried to demonstrate influencing factors that can improve or exacerbate this development, as well as predictive factors that might select a population at risk to assist with early childhood support.
It was a study of 70 children affected with FGR. FGR was based on these definitions: birth weight below the 3rd percentile or birth weight below the 10th percentile with an abnormal hemodynamic Doppler study. Neurodevelopment was assessed at 6 years old by means of Batelle Development Inventory. A global development quotient under a 100 score was considered a neurodevelopment delay. All variables regarding pregnancy care, delivery episode, postpartum, neonatal care, sociodemographic issues, and the need for support in the first years were studied.
The mean gestational age at diagnosis was 33.14 weeks (standard deviation (SD = 4.31), with 32.9% of early-onset diagnoses. The mean gestational age at delivery was 35.61 (SD = 3.21), and the cesarean rate was 64.3%. The average age of the children at the moment of the evaluation was 76.20-month-old (SD = 3.70). The mean global development quotient was 97.28 (SD = 13.97). We were able to record a 57.1% of global development delay. In the cases of cognition, only 17.1% of the children registered a delay. Motor and communication skills were the most frequently affected. We discovered that socioeconomic status was positively related to the global development quotient, as well as both gestational age at delivery and middle cerebral artery pulsatility index was positively related to the global development quotient.
We found a higher neurodevelopment delay rate (57.1%). We could relate a higher gestational age at delivery and a higher MCA percentile with better global neurodevelopment quotients.
It was a study of 70 children affected with FGR. FGR was based on these definitions: birth weight below the 3rd percentile or birth weight below the 10th percentile with an abnormal hemodynamic Doppler study. Neurodevelopment was assessed at 6 years old by means of Batelle Development Inventory. A global development quotient under a 100 score was considered a neurodevelopment delay. All variables regarding pregnancy care, delivery episode, postpartum, neonatal care, sociodemographic issues, and the need for support in the first years were studied.
The mean gestational age at diagnosis was 33.14 weeks (standard deviation (SD = 4.31), with 32.9% of early-onset diagnoses. The mean gestational age at delivery was 35.61 (SD = 3.21), and the cesarean rate was 64.3%. The average age of the children at the moment of the evaluation was 76.20-month-old (SD = 3.70). The mean global development quotient was 97.28 (SD = 13.97). We were able to record a 57.1% of global development delay. In the cases of cognition, only 17.1% of the children registered a delay. Motor and communication skills were the most frequently affected. We discovered that socioeconomic status was positively related to the global development quotient, as well as both gestational age at delivery and middle cerebral artery pulsatility index was positively related to the global development quotient.
We found a higher neurodevelopment delay rate (57.1%). We could relate a higher gestational age at delivery and a higher MCA percentile with better global neurodevelopment quotients.
摘要：
这项研究旨在描述六岁时胎儿生长受限儿童的神经发育。其次,我们试图证明可以改善或加剧这种发展的影响因素，以及可能选择处于危险中的人群来协助早期儿童支持的预测因素。
这是一项针对70名FGR患儿的研究。FGR基于以下定义：出生体重低于第3百分位数或出生体重低于第10百分位数，血流动力学多普勒研究异常。通过Batelle发育量表评估6岁时的神经发育。在100分以下的全球发育商被认为是神经发育延迟。关于怀孕护理的所有变量，交付插曲,产后,新生儿护理,社会人口问题，并研究了第一年的支持需求。
诊断时的平均胎龄为33.14周（标准差（SD=4.31），有32.9%的早发性诊断。分娩时的平均胎龄为35.61（SD=3.21），剖宫产率为64.3%。评估时儿童的平均年龄为76.20个月大（SD=3.70）。全球平均发展商为97.28（SD=13.97）。我们记录了全球开发延迟的57.1％。在认知的情况下，只有17.1%的儿童登记延误。运动和沟通技能是最常见的影响。我们发现，社会经济地位与全球发展商呈正相关，分娩时胎龄和大脑中动脉搏动指数与全球发育商呈正相关。
我们发现更高的神经发育延迟率（57.1％）。我们可以将较高的分娩胎龄和较高的MCA百分位数与更好的全球神经发育商联系起来。
这是一项针对70名FGR患儿的研究。FGR基于以下定义：出生体重低于第3百分位数或出生体重低于第10百分位数，血流动力学多普勒研究异常。通过Batelle发育量表评估6岁时的神经发育。在100分以下的全球发育商被认为是神经发育延迟。关于怀孕护理的所有变量，交付插曲,产后,新生儿护理,社会人口问题，并研究了第一年的支持需求。
诊断时的平均胎龄为33.14周（标准差（SD=4.31），有32.9%的早发性诊断。分娩时的平均胎龄为35.61（SD=3.21），剖宫产率为64.3%。评估时儿童的平均年龄为76.20个月大（SD=3.70）。全球平均发展商为97.28（SD=13.97）。我们记录了全球开发延迟的57.1％。在认知的情况下，只有17.1%的儿童登记延误。运动和沟通技能是最常见的影响。我们发现，社会经济地位与全球发展商呈正相关，分娩时胎龄和大脑中动脉搏动指数与全球发育商呈正相关。
我们发现更高的神经发育延迟率（57.1％）。我们可以将较高的分娩胎龄和较高的MCA百分位数与更好的全球神经发育商联系起来。
