PDF(Pubmed)
Abstract：
The role of astrogliosis in the pathology of brain aging and neurodegenerative diseases has recently drawn great attention. Imidazoline-2 binding sites represent a possible target to map the distribution of reactive astrocytes. In this study, we use 11C-BU99008, an imidazoline-2 binding sites-specific PET radioligand, to image reactive astrocytes in vivo in healthy controls and patients with established Parkinson\'s disease dementia. Eighteen healthy controls (age: 45-78 years) and six patients with Parkinson\'s disease dementia (age: 64-77 years) had one 11C-BU99008 PET-CT scan with arterial input function. All subjects underwent one 3 T MRI brain scan to facilitate the analysis of the PET data and to capture individual cerebral atrophy. Regional 11C-BU99008 volumes of distribution were calculated for each subject by the two-tissue compartmental modelling. Positive correlations between 11C-BU99008 volumes of distribution values and age were found for all tested regions across the brain within healthy controls (P < 0.05); furthermore, multiple regression indicated that aging affects 11C-BU99008 volumes of distribution values in a region-specific manner. Independent samples t-test indicated that there was no significant group difference in 11C-BU99008 volumes of distribution values between Parkinson\'s disease dementia (n = 6; mean age = 71.97 ± 4.66 years) and older healthy controls (n = 9; mean age = 71.90 ± 5.51 years). Our data set shows that astrogliosis is common with aging in a region-specific manner. However, in this set-up, 11C-BU99008 PET cannot differentiate patients with Parkinson\'s disease dementia from healthy controls of similar age.
摘要：
星形胶质细胞增生在脑老化和神经退行性疾病病理中的作用最近引起了极大的关注。咪唑啉-2结合位点代表了绘制反应性星形胶质细胞分布的可能靶标。在这项研究中,我们使用11C-BU99008，一种咪唑啉-2结合位点特异性PET放射性配体，在健康对照和帕金森病痴呆患者体内成像反应性星形胶质细胞。18名健康对照(年龄:45-78岁)和6名帕金森病痴呆患者(年龄:64-77岁)接受了1次具有动脉输入功能的11C-BU99008PET-CT扫描。所有受试者均进行了一次3TMRI脑部扫描，以促进对PET数据的分析并捕获个体脑萎缩。通过两组织隔室建模计算每个受试者的区域11C-BU99008分布体积。11C-BU99008体积的分布值和年龄之间的正相关被发现在整个大脑中的所有测试区域在健康对照组(P<0.05);此外,多元回归表明，老化以特定区域的方式影响11C-BU99008体积的分布值。独立样本t检验表明，帕金森病痴呆（n=6；平均年龄=71.97±4.66岁）和老年健康对照组（n=9；平均年龄=71.90±5.51岁）之间11C-BU99008体积分布值没有显着差异。我们的数据集显示，星形胶质细胞增生以特定区域的方式与衰老有关。然而,在这个设置中，11C-BU99008PET不能区分帕金森病痴呆患者与相似年龄的健康对照。
