PDF(Pubmed)
Abstract：
UNASSIGNED: This study investigated the changes in health-related quality of life from diagnosis to 1 year after diagnosis in breast cancer (BC) patients and the influence of clinical, psychological, and sociodemographic variables. An additional aim was to explore the mediating and moderating effects of resilience on changes in health-related quality of life.
UNASSIGNED: A longitudinal population-based study was conducted in southern Sweden. Newly diagnosed BC patients filled in measures of health-related quality of life, resilience, and sociodemographic variables at diagnosis (N = 980) and 1 year post-diagnosis (N = 780). Clinical variables were extracted from the Swedish national breast cancer quality registry. Mixed-model analyses were performed.
UNASSIGNED: Most health-related quality of life outcomes declined from diagnosis to 1 year post-diagnosis. Role limitations due to emotional problems remained the same, whereas mental health improved. Lower health-related quality of life outcomes were associated with symptomatic detection and axillary dissection. Patients with a higher TNM stage and histologic grade and estrogen receptor (ER)-negative and human epidermal growth factor 2 (HER2)-positive status, who received chemotherapy, antibody therapy, or bisphosphonate therapy, had a steeper decline in outcomes. Changes in resilience were positively associated with all outcomes but did not mediate or moderate changes in any. Resilience at baseline moderated changes in bodily pain, vitality, and mental health, with higher baseline resilience being associated with a steeper decline, possibly due to floor or ceiling effects. Patients with lower socioeconomic status, educational level, and older age had a lower health-related quality of life.
UNASSIGNED: Physical health-related quality of life among breast cancer patients declined 1 year post-diagnosis, whereas mental health-related quality of life improved. Low resilient patients may be especially vulnerable at diagnosis. Biopsychosocial assessment at diagnosis can help identify patients who may require additional support. A multidimensional treatment plan should be started early to help overcome the problems in everyday activities.
UNASSIGNED: A longitudinal population-based study was conducted in southern Sweden. Newly diagnosed BC patients filled in measures of health-related quality of life, resilience, and sociodemographic variables at diagnosis (N = 980) and 1 year post-diagnosis (N = 780). Clinical variables were extracted from the Swedish national breast cancer quality registry. Mixed-model analyses were performed.
UNASSIGNED: Most health-related quality of life outcomes declined from diagnosis to 1 year post-diagnosis. Role limitations due to emotional problems remained the same, whereas mental health improved. Lower health-related quality of life outcomes were associated with symptomatic detection and axillary dissection. Patients with a higher TNM stage and histologic grade and estrogen receptor (ER)-negative and human epidermal growth factor 2 (HER2)-positive status, who received chemotherapy, antibody therapy, or bisphosphonate therapy, had a steeper decline in outcomes. Changes in resilience were positively associated with all outcomes but did not mediate or moderate changes in any. Resilience at baseline moderated changes in bodily pain, vitality, and mental health, with higher baseline resilience being associated with a steeper decline, possibly due to floor or ceiling effects. Patients with lower socioeconomic status, educational level, and older age had a lower health-related quality of life.
UNASSIGNED: Physical health-related quality of life among breast cancer patients declined 1 year post-diagnosis, whereas mental health-related quality of life improved. Low resilient patients may be especially vulnerable at diagnosis. Biopsychosocial assessment at diagnosis can help identify patients who may require additional support. A multidimensional treatment plan should be started early to help overcome the problems in everyday activities.
摘要：
未经评估：这项研究调查了乳腺癌（BC）患者从诊断到诊断后1年与健康相关的生活质量的变化以及临床，心理,和社会人口统计学变量。另一个目的是探索韧性对健康相关生活质量变化的中介和调节作用。
UNASSIGNED：在瑞典南部进行了一项基于人群的纵向研究。新诊断的BC患者填写健康相关生活质量的措施，弹性，诊断时(N=980)和诊断后1年(N=780)的社会人口统计学变量。从瑞典国家乳腺癌质量登记处提取临床变量。进行了混合模型分析。
未经评估：大多数与健康相关的生活质量结果从诊断到诊断后1年下降。由于情感问题的角色限制保持不变，而心理健康有所改善。较低的健康相关生活质量结果与症状检测和腋窝解剖有关。具有较高的TNM分期和组织学分级以及雌激素受体（ER）阴性和人表皮生长因子2（HER2）阳性状态的患者，接受化疗的人，抗体疗法,或双膦酸盐治疗，结果急剧下降。韧性的变化与所有结果呈正相关，但没有介导或适度的变化。基线时的弹性调节了身体疼痛的变化，活力,和心理健康，较高的基线弹性与较陡的下降相关，可能是由于地板或天花板的影响。社会经济地位较低的患者，教育水平,老年人的健康相关生活质量较低.
未经评估：乳腺癌患者的身体健康相关生活质量在诊断后1年下降，而心理健康相关的生活质量改善。低弹性患者在诊断时可能特别脆弱。诊断时的生物心理社会评估可以帮助识别可能需要额外支持的患者。应尽早启动多维治疗计划，以帮助克服日常活动中的问题。
UNASSIGNED：在瑞典南部进行了一项基于人群的纵向研究。新诊断的BC患者填写健康相关生活质量的措施，弹性，诊断时(N=980)和诊断后1年(N=780)的社会人口统计学变量。从瑞典国家乳腺癌质量登记处提取临床变量。进行了混合模型分析。
未经评估：大多数与健康相关的生活质量结果从诊断到诊断后1年下降。由于情感问题的角色限制保持不变，而心理健康有所改善。较低的健康相关生活质量结果与症状检测和腋窝解剖有关。具有较高的TNM分期和组织学分级以及雌激素受体（ER）阴性和人表皮生长因子2（HER2）阳性状态的患者，接受化疗的人，抗体疗法,或双膦酸盐治疗，结果急剧下降。韧性的变化与所有结果呈正相关，但没有介导或适度的变化。基线时的弹性调节了身体疼痛的变化，活力,和心理健康，较高的基线弹性与较陡的下降相关，可能是由于地板或天花板的影响。社会经济地位较低的患者，教育水平,老年人的健康相关生活质量较低.
未经评估：乳腺癌患者的身体健康相关生活质量在诊断后1年下降，而心理健康相关的生活质量改善。低弹性患者在诊断时可能特别脆弱。诊断时的生物心理社会评估可以帮助识别可能需要额外支持的患者。应尽早启动多维治疗计划，以帮助克服日常活动中的问题。
