PDF(Pubmed)
Abstract：
UNASSIGNED: Cardiac surgery associated AKI (CSA-AKI) complicates recovery and may be associated with a greater risk of developing chronic kidney disease and mortality. The aim of this study was to assess long-term clinical consequences of transient increased activity of urinary enzymes after cardiac surgery (CS).
UNASSIGNED: An observational study was conducted in a group of 88 adult patients undergoing planned coronary artery bypass grafting (CABG), but all samples were obtained from 79 patients. The activity of urinary enzymes: N-acetyl-beta-glucosaminidase (NAG), arylsulfatase A (ASA) and beta-glucuronidase was evaluated in sequential urine samples. A comparative analysis of biochemical parameters was performed regarding the occurrence of acute kidney injury (AKI) defined by KIDGO at 24 hours, at day 30 and 5-years after the operation.
UNASSIGNED: During the first 24 hours after CS AKI was diagnosed in 13 patients. A comparison of the activity of urinary enzymes in pre-defined time-points showed significant differences for ASA and NAG (post OP-sample p < 0.028 and p < 0.022; POD 1 sample p < 0.004 and p < 0.001 respectively). No patient had any biochemical or clinical features of kidney failure at day 30. In the AKI group kidney failure was diagnosed in 36% of patients within 5 years of follow-up as opposed to 5% in the no AKI group. The activities of tubular enzymes in urine reflect a general injury of kidney tubules during and after the operation. However, they are not ideal biomarkers for prediction of the degree of kidney injury and further poor prognosis of CS-AKI.
UNASSIGNED: An observational study was conducted in a group of 88 adult patients undergoing planned coronary artery bypass grafting (CABG), but all samples were obtained from 79 patients. The activity of urinary enzymes: N-acetyl-beta-glucosaminidase (NAG), arylsulfatase A (ASA) and beta-glucuronidase was evaluated in sequential urine samples. A comparative analysis of biochemical parameters was performed regarding the occurrence of acute kidney injury (AKI) defined by KIDGO at 24 hours, at day 30 and 5-years after the operation.
UNASSIGNED: During the first 24 hours after CS AKI was diagnosed in 13 patients. A comparison of the activity of urinary enzymes in pre-defined time-points showed significant differences for ASA and NAG (post OP-sample p < 0.028 and p < 0.022; POD 1 sample p < 0.004 and p < 0.001 respectively). No patient had any biochemical or clinical features of kidney failure at day 30. In the AKI group kidney failure was diagnosed in 36% of patients within 5 years of follow-up as opposed to 5% in the no AKI group. The activities of tubular enzymes in urine reflect a general injury of kidney tubules during and after the operation. However, they are not ideal biomarkers for prediction of the degree of kidney injury and further poor prognosis of CS-AKI.
摘要：
未经证实：心脏手术相关的AKI(CSA-AKI)会使康复复杂化，并可能与更高的慢性肾病和死亡风险相关。这项研究的目的是评估心脏手术（CS）后尿酶活性短暂增加的长期临床后果。
UNASSIGNED：一项观察性研究是在一组88名计划进行冠状动脉旁路移植术（CABG）的成年患者中进行的，但所有样本均来自79名患者。尿酶的活性：N-乙酰-β-氨基葡萄糖苷酶（NAG），在连续的尿液样品中评估了芳基硫酸酯酶A（ASA）和β-葡糖醛酸糖苷酶。在24小时，对由KIDGO定义的急性肾损伤（AKI）的发生进行了生化参数的比较分析。手术后30天和5年。
UNASSIGNED：在CS后的最初24小时内，有13例患者被诊断为AKI。在预定时间点的尿酶活性的比较显示了ASA和NAG的显着差异（OP样品后p<0.028和p<0.022；POD1样品p<0.004和p<0.001）。在第30天,没有患者具有肾衰竭的任何生化或临床特征。在AKI组中，在随访的5年内，有36％的患者诊断出肾衰竭，而在无AKI组中，这一比例为5％。尿液中肾小管酶的活性反映了手术期间和术后肾小管的一般损伤。然而,它们不是预测肾脏损伤程度和CS-AKI预后不良的理想生物标志物.
UNASSIGNED：一项观察性研究是在一组88名计划进行冠状动脉旁路移植术（CABG）的成年患者中进行的，但所有样本均来自79名患者。尿酶的活性：N-乙酰-β-氨基葡萄糖苷酶（NAG），在连续的尿液样品中评估了芳基硫酸酯酶A（ASA）和β-葡糖醛酸糖苷酶。在24小时，对由KIDGO定义的急性肾损伤（AKI）的发生进行了生化参数的比较分析。手术后30天和5年。
UNASSIGNED：在CS后的最初24小时内，有13例患者被诊断为AKI。在预定时间点的尿酶活性的比较显示了ASA和NAG的显着差异（OP样品后p<0.028和p<0.022；POD1样品p<0.004和p<0.001）。在第30天,没有患者具有肾衰竭的任何生化或临床特征。在AKI组中，在随访的5年内，有36％的患者诊断出肾衰竭，而在无AKI组中，这一比例为5％。尿液中肾小管酶的活性反映了手术期间和术后肾小管的一般损伤。然而,它们不是预测肾脏损伤程度和CS-AKI预后不良的理想生物标志物.
