Abstract：
Lacosamide is a novel antiepileptic drug. Although many antiepileptic drugs reportedly pose a risk to fetuses, patients with epilepsy are advised to continue their medications during pregnancy. There have been few reports on lacosamide use during pregnancy, and its effects on the fetus remain unclear. Here, we report a case of lacosamide use during pregnancy. The 33-year-old patient was treated with oral lacosamide (400 mg/d) for symptomatic partial epilepsy. She was concomitantly treated with folic acid (5 mg/d) beginning 4 days before her last menstrual cycle. She was also concomitantly treated with oral perampanel (2 mg/d) at 5-7 weeks\' gestation for seizure control but discontinued perampanel after the pregnancy was discovered. She progressed through her pregnancy with only mild seizures. Fetal growth was normal and ultrasonography revealed no external malformations. The patient had an elective cesarean section at 37 weeks and 2 days owing to a previous post-cesarean pregnancy. Her baby boy weighed 3025 g; his Apgar score was 8 and 9, 1 and 5 min, respectively, and his umbilical artery blood pH was 7.348. He had no congenital anomalies and no neonatal drug withdrawal symptoms. This suggests that lacosamide may have a low risk of teratogenicity and fetal toxicity. Thus, this case is valuable for clinicians who are considering the administration of antiepileptic drugs during pregnancy. In the future, more reports on the use of lacosamide during pregnancy should be collected.
摘要：
拉科酰胺是一种新型的抗癫痫药物。尽管据报道许多抗癫痫药物对胎儿有风险，建议癫痫患者在怀孕期间继续服药.关于怀孕期间使用拉科沙胺的报道很少，其对胎儿的影响尚不清楚。这里,我们报告1例怀孕期间使用拉科沙胺。33岁患者口服拉科沙胺（400mg/d）治疗症状性部分癫痫。在末次月经周期前4天开始，她同时接受叶酸（5mg/d）治疗。在妊娠5-7周时，她还同时接受口服潘帕奈（2mg/d）治疗以控制癫痫发作，但在发现怀孕后停用潘帕奈。她怀孕了，只有轻微的癫痫发作。胎儿生长正常，超声检查未发现外部畸形。由于先前的剖宫产后妊娠，该患者在37周和2天时进行了选择性剖宫产。她的男婴重3025克；他的阿普加评分是8和9，1和5分钟，分别,他的脐动脉血pH值为7.348。他没有先天性异常，也没有新生儿戒断症状。这表明拉科沙胺可能具有低的致畸性和胎儿毒性风险。因此，对于正在考虑在妊娠期服用抗癫痫药物的临床医生来说,这个病例是有价值的.在未来,应该收集更多关于怀孕期间使用拉科沙胺的报告。
