Abstract：
BACKGROUND: It is thought that genetic factors may play an important role in the development of coronary artery disease (CAD). Several studies report that AGT polymorphism is implicated in CAD susceptibility, but these results contradict those of the other studies with the associations being unclear in the Eastern Asian population. Therefore, meta-analysis was performed to evaluate this relationship.
METHODS: Publication databases were used to search for eligible relevant studies and valid data were extracted from studies meeting the inclusion criteria. Subsequently, odds ratios (ORs) with 95 % confidence intervals (CIs), were used to assess the strength of the association between AGT polymorphism and CAD risk.
RESULTS: Seven eligible studies published only in English were included in the present meta-analysis. In the Eastern Asian population, CAD susceptibility was shown to be related to AGT M235T under the heterozygote model (OR = 0.19). Stratified analysis indicated there was a significant relationship between AGT M235T and CAD risk in China under allelic (OR = 1.34), dominant (OR = 1.43), and heterozygote (OR = 1.62) models. The results showed that the T174M polymorphism was significantly associated with CAD risk in recessive (OR = 2.28) and homozygote (OR = 2.37) models in the Eastern Asian population.
CONCLUSIONS: In the Eastern Asian population, especially the Chinese, the M235T of AGT is associated with CAD susceptibility. The T174M polymorphisms were associated with CAD risk in the Eastern Asian population.
METHODS: Publication databases were used to search for eligible relevant studies and valid data were extracted from studies meeting the inclusion criteria. Subsequently, odds ratios (ORs) with 95 % confidence intervals (CIs), were used to assess the strength of the association between AGT polymorphism and CAD risk.
RESULTS: Seven eligible studies published only in English were included in the present meta-analysis. In the Eastern Asian population, CAD susceptibility was shown to be related to AGT M235T under the heterozygote model (OR = 0.19). Stratified analysis indicated there was a significant relationship between AGT M235T and CAD risk in China under allelic (OR = 1.34), dominant (OR = 1.43), and heterozygote (OR = 1.62) models. The results showed that the T174M polymorphism was significantly associated with CAD risk in recessive (OR = 2.28) and homozygote (OR = 2.37) models in the Eastern Asian population.
CONCLUSIONS: In the Eastern Asian population, especially the Chinese, the M235T of AGT is associated with CAD susceptibility. The T174M polymorphisms were associated with CAD risk in the Eastern Asian population.
摘要：
背景：人们认为遗传因素可能在冠状动脉疾病（CAD）的发展中起重要作用。一些研究报道AGT多态性与CAD易感性有关,但是这些结果与其他研究的结果相矛盾，在东亚人群中的相关性尚不清楚。因此,进行荟萃分析以评估这种关系。
方法：使用出版物数据库搜索符合条件的相关研究，并从符合纳入标准的研究中提取有效数据。随后，具有95%置信区间(CI)的优势比(OR)，用于评估AGT多态性与CAD风险之间的关联强度。
结果：本荟萃分析中纳入了7项仅以英文发表的合格研究。在东亚人口中，在杂合子模型下，CAD易感性与AGTM235T相关（OR=0.19）。分层分析表明，在等位基因下，AGTM235T与中国CAD风险之间存在显着关系（OR=1.34）。显性（OR=1.43），和杂合子(OR=1.62)模型。结果表明，在东亚人群中，T174M多态性与隐性（OR=2.28）和纯合子（OR=2.37）模型的CAD风险显着相关。
结论：在东亚人口中，尤其是中国人,AGT的M235T与CAD易感性相关。T174M多态性与东亚人群的CAD风险相关。
方法：使用出版物数据库搜索符合条件的相关研究，并从符合纳入标准的研究中提取有效数据。随后，具有95%置信区间(CI)的优势比(OR)，用于评估AGT多态性与CAD风险之间的关联强度。
结果：本荟萃分析中纳入了7项仅以英文发表的合格研究。在东亚人口中，在杂合子模型下，CAD易感性与AGTM235T相关（OR=0.19）。分层分析表明，在等位基因下，AGTM235T与中国CAD风险之间存在显着关系（OR=1.34）。显性（OR=1.43），和杂合子(OR=1.62)模型。结果表明，在东亚人群中，T174M多态性与隐性（OR=2.28）和纯合子（OR=2.37）模型的CAD风险显着相关。
结论：在东亚人口中，尤其是中国人,AGT的M235T与CAD易感性相关。T174M多态性与东亚人群的CAD风险相关。
