Abstract：
The human papillomavirus (HPV) vaccine is recommended for adolescents and young adults to prevent HPV-related cancers and genital warts. However, HPV vaccine uptake among the target age groups is suboptimal.
The aim of this infodemiology study was to examine public online searches in the United States related to the HPV vaccine from January 2010 to December 2021.
Google Trends (GT) was used to explore online searches related to the HPV vaccine from January 1, 2010, to December 31, 2021. Online searches and queries on the HPV vaccine were investigated using relative search volumes (RSVs). Analysis of variance was performed to investigate quarterly differences in HPV vaccine searches in each year from 2010 to 2021. A joinpoint regression was used to identify statistically significant changes over time; the α level was set to .05.
The year-wise online search volume related to the HPV vaccine increased from 2010 to 2021, often following federal changes related to vaccine administration. Joinpoint regression analysis showed that HPV vaccine searches significantly increased on average by 8.6% (95% CI 5.9%-11.4%) across each year from 2010 to 2021. Moreover, HPV vaccine searches demonstrated a similar pattern across years, with search interest increasing through August nearly every year. At the state level, the highest 12-year mean RSV was observed in California (59.9, SD 14.3) and the lowest was observed in Wyoming (17.4, SD 8.5) during the period of 2010-2021.
Online searches related to the HPV vaccine increased by an average of 8.6% across each year from 2010 to 2021, with noticeable spikes corresponding to key changes in vaccine recommendations. We identified patterns across years and differences at the state level in the online search interest related to the HPV vaccine. Public health organizations can use GT as a tool to characterize the public interest in and promote the HPV vaccine in the United States.
The aim of this infodemiology study was to examine public online searches in the United States related to the HPV vaccine from January 2010 to December 2021.
Google Trends (GT) was used to explore online searches related to the HPV vaccine from January 1, 2010, to December 31, 2021. Online searches and queries on the HPV vaccine were investigated using relative search volumes (RSVs). Analysis of variance was performed to investigate quarterly differences in HPV vaccine searches in each year from 2010 to 2021. A joinpoint regression was used to identify statistically significant changes over time; the α level was set to .05.
The year-wise online search volume related to the HPV vaccine increased from 2010 to 2021, often following federal changes related to vaccine administration. Joinpoint regression analysis showed that HPV vaccine searches significantly increased on average by 8.6% (95% CI 5.9%-11.4%) across each year from 2010 to 2021. Moreover, HPV vaccine searches demonstrated a similar pattern across years, with search interest increasing through August nearly every year. At the state level, the highest 12-year mean RSV was observed in California (59.9, SD 14.3) and the lowest was observed in Wyoming (17.4, SD 8.5) during the period of 2010-2021.
Online searches related to the HPV vaccine increased by an average of 8.6% across each year from 2010 to 2021, with noticeable spikes corresponding to key changes in vaccine recommendations. We identified patterns across years and differences at the state level in the online search interest related to the HPV vaccine. Public health organizations can use GT as a tool to characterize the public interest in and promote the HPV vaccine in the United States.
摘要：
建议青少年和年轻人使用人乳头瘤病毒（HPV）疫苗，以预防与HPV相关的癌症和生殖器疣。然而,目标年龄组中的HPV疫苗摄取次优。
这项信息流行病学研究的目的是检查2010年1月至2021年12月美国与HPV疫苗相关的公共在线搜索。
从2010年1月1日至2021年12月31日，Google趋势（GT）用于探索与HPV疫苗相关的在线搜索。使用相对搜索量(RSV)研究对HPV疫苗的在线搜索和查询。进行方差分析以调查2010年至2021年每年HPV疫苗搜索的季度差异。使用连接点回归来确定随时间的统计学显著变化;α水平设置为.05。从2010年到2021年，与HPV疫苗相关的年度在线搜索量增加，通常是在联邦与疫苗管理相关的变化之后。Joinpoint回归分析显示，从2010年到2021年，HPV疫苗搜索量每年平均增加8.6％（95％CI5.9％-11.4％）。此外，HPV疫苗搜索显示出多年来相似的模式，搜索兴趣几乎每年8月都在增加。在州一级,在2010-2021年期间,12年平均RSV最高的是加利福尼亚州(59.9,SD14.3),最低的是怀俄明州(17.4,SD8.5).从2010年到2021年，与HPV疫苗相关的在线搜索每年平均增长8.6%，与疫苗推荐的关键变化相对应的峰值明显。我们在与HPV疫苗相关的在线搜索兴趣中确定了不同年份的模式和州一级的差异。公共卫生组织可以使用GT作为表征公众对美国HPV疫苗的兴趣和推广的工具。
这项信息流行病学研究的目的是检查2010年1月至2021年12月美国与HPV疫苗相关的公共在线搜索。
从2010年1月1日至2021年12月31日，Google趋势（GT）用于探索与HPV疫苗相关的在线搜索。使用相对搜索量(RSV)研究对HPV疫苗的在线搜索和查询。进行方差分析以调查2010年至2021年每年HPV疫苗搜索的季度差异。使用连接点回归来确定随时间的统计学显著变化;α水平设置为.05。从2010年到2021年，与HPV疫苗相关的年度在线搜索量增加，通常是在联邦与疫苗管理相关的变化之后。Joinpoint回归分析显示，从2010年到2021年，HPV疫苗搜索量每年平均增加8.6％（95％CI5.9％-11.4％）。此外，HPV疫苗搜索显示出多年来相似的模式，搜索兴趣几乎每年8月都在增加。在州一级,在2010-2021年期间,12年平均RSV最高的是加利福尼亚州(59.9,SD14.3),最低的是怀俄明州(17.4,SD8.5).从2010年到2021年，与HPV疫苗相关的在线搜索每年平均增长8.6%，与疫苗推荐的关键变化相对应的峰值明显。我们在与HPV疫苗相关的在线搜索兴趣中确定了不同年份的模式和州一级的差异。公共卫生组织可以使用GT作为表征公众对美国HPV疫苗的兴趣和推广的工具。
