PDF(Pubmed)
Abstract：
Our study intended to investigate five cytokine gene single nucleotide polymorphisms (SNPs) and their associations with prostate cancer risk. Genotypes of five cytokine gene SNPs were detected by MassARRAY for blood samples from a group of patients with prostate cancer (n = 90) and a control group (n = 140) in central China. The differences in tumor clinical stages, Gleason scores, and PSA values in patients with prostate cancer were also investigated. The frequencies of the five cytokine gene SNPs (L-1β rs16944, IL-4 rs2070874, IL-4rs2227284, IL-16 rs7175701, and IL-16 rs11556218) genotypes were not found to be significantly mutated in prostate cancer patients compared with the control group. In addition, for five cytokine gene SNPs genotypic comparisons, patients with different Gleason scores, clinical stages, and PSA values were grouped into two subgroups. There was also no statistically significant association in all these subgroups. Our study suggests that cytokine gene polymorphisms may not be a risk factor for prostate cancer in a central Chinese population. Nevertheless, more large-scale studies on the Chinese population are necessary to examine our conclusions. The discovery of cytokine gene polymorphisms related to prostate cancer could update our understanding of the etiology and improve our knowledge of the early detection, diagnosis, and treatment of prostate cancer.
摘要：
我们的研究旨在研究五种细胞因子基因单核苷酸多态性（SNP）及其与前列腺癌风险的关系。在中国中部的一组前列腺癌患者（n=90）和一个对照组（n=140）的血液样本中，通过MassARRAY检测了五个细胞因子基因SNP的基因型。肿瘤临床分期的差异,格里森分数，我们还研究了前列腺癌患者的PSA值。与对照组相比，前列腺癌患者中五个细胞因子基因SNP（L-1βrs16944，IL-4rs2070874，IL-4rs2227284，IL-16rs7175701和IL-16rs11556218）基因型的频率未发现显着突变。此外,对于五个细胞因子基因SNP基因型比较，不同Gleason评分的患者,临床分期,和PSA值分为两个亚组。在所有这些亚组中也没有统计学上显著的关联。我们的研究表明，在中国中部人群中，细胞因子基因多态性可能不是前列腺癌的危险因素。然而，有必要对中国人口进行更大规模的研究来检验我们的结论。发现与前列腺癌相关的细胞因子基因多态性可以更新我们对其病因的认识,提高我们对早期发现的认识,诊断,和前列腺癌的治疗。
