Abstract：
BACKGROUND: It is well known that traffic injuries still represent one of the main causes of death and that high blood alcohol concentrations while driving significantly increase the occurrence of accidents. However, only limited literature on the correlation between chronic alcohol abuse and accident risk is available. The aim of the present study was to investigate the hypothesis of an association between elevated concentrations of carbohydrate deficient transferrin (CDT) and the occurrence of alcohol-related traffic accidents.
METHODS: The analytical determinations of BAC and CDT were performed following certified methods in HS-GC-FID and HPLC, respectively. For BAC, 0.50 g/L was used as cut-off, whereas 2.0% was used for CDT, according to the standardisation proposed by IFCC. A total of 929 drivers, tested for BAC at the time of hospital admission after a traffic accident, were classified into two groups: InjDr 1 (BAC ≤ 0.50 g/L) and InjDr 2 (BAC>0.50 g/L); all drivers were also tested for CDT.
RESULTS: InjDr 1 included 674 individuals, only 2.5% showing a CDT above the cutoff, whereas InjDr 2 group consisted of 255 subjects, 28.6% testing positive for CDT (Odds Ratio 15.5). When subdividing the InjDr group into increasing classes of CDT, a steady increase in the percentage of BAC-positive drivers was appreciated. Moreover, average BAC was found to parallel each class of CDT.
CONCLUSIONS: The reported data strongly support the use of CDT as a biomarker of increased risk of alcohol-related traffic accidents in the procedures of re-granting of the driving license upon confiscation for \"drink driving\".
METHODS: The analytical determinations of BAC and CDT were performed following certified methods in HS-GC-FID and HPLC, respectively. For BAC, 0.50 g/L was used as cut-off, whereas 2.0% was used for CDT, according to the standardisation proposed by IFCC. A total of 929 drivers, tested for BAC at the time of hospital admission after a traffic accident, were classified into two groups: InjDr 1 (BAC ≤ 0.50 g/L) and InjDr 2 (BAC>0.50 g/L); all drivers were also tested for CDT.
RESULTS: InjDr 1 included 674 individuals, only 2.5% showing a CDT above the cutoff, whereas InjDr 2 group consisted of 255 subjects, 28.6% testing positive for CDT (Odds Ratio 15.5). When subdividing the InjDr group into increasing classes of CDT, a steady increase in the percentage of BAC-positive drivers was appreciated. Moreover, average BAC was found to parallel each class of CDT.
CONCLUSIONS: The reported data strongly support the use of CDT as a biomarker of increased risk of alcohol-related traffic accidents in the procedures of re-granting of the driving license upon confiscation for \"drink driving\".
摘要：
背景：众所周知，交通伤害仍然是导致死亡的主要原因之一，并且驾驶时血液中的高酒精浓度显着增加了事故的发生。然而,关于慢性酒精滥用与意外风险之间的相关性的文献有限.本研究的目的是研究碳水化合物缺乏转铁蛋白（CDT）浓度升高与酒精相关的交通事故发生之间的关联的假设。
方法：BAC和CDT的分析测定按照HS-GC-FID和HPLC中的认证方法进行，分别。对于BAC，0.50g/L用作截止值，而2.0%用于CDT，根据IFCC提出的标准化。共有929名司机，在交通事故后入院时进行BAC测试，分为两组：InjDr1（BAC≤0.50g/L）和InjDr2（BAC>0.50g/L）；还测试了所有驾驶员的CDT。
结果：InjDr1包括674个人，只有2.5%的人显示CDT高于临界值，而InjDr2组由255名受试者组成，28.6%的CDT检测为阳性（赔率比15.5）。当将InjDr组细分为越来越多的CDT类时，BAC阳性驱动因素百分比的稳定增长受到赞赏。此外，发现平均BAC与各类CDT平行。
结论：报告的数据强烈支持在“酒后驾驶”被没收时重新颁发驾驶执照的程序中，使用CDT作为酒精相关交通事故风险增加的生物标志物。
方法：BAC和CDT的分析测定按照HS-GC-FID和HPLC中的认证方法进行，分别。对于BAC，0.50g/L用作截止值，而2.0%用于CDT，根据IFCC提出的标准化。共有929名司机，在交通事故后入院时进行BAC测试，分为两组：InjDr1（BAC≤0.50g/L）和InjDr2（BAC>0.50g/L）；还测试了所有驾驶员的CDT。
结果：InjDr1包括674个人，只有2.5%的人显示CDT高于临界值，而InjDr2组由255名受试者组成，28.6%的CDT检测为阳性（赔率比15.5）。当将InjDr组细分为越来越多的CDT类时，BAC阳性驱动因素百分比的稳定增长受到赞赏。此外，发现平均BAC与各类CDT平行。
结论：报告的数据强烈支持在“酒后驾驶”被没收时重新颁发驾驶执照的程序中，使用CDT作为酒精相关交通事故风险增加的生物标志物。
