Abstract：
UNASSIGNED: Undescended testes (UDT) or cryptorchidism is a common congenital disability characterised by the absence of at least one testicle from the scrotum. The primary aim of surgical correction is to preserve fertility potential and prevent complications including trauma, malignancy, hernia and torsion. Often, children, especially in developing countries, present late with UDT. The effect of surgical correction in the recovery of Sertoli cell function in children aged more than 2 years is not apparent. The present study was conducted to study the change in inhibin-B level as a marker of Sertoli cell function in surgically corrected UDT in a heterogeneous population.
UNASSIGNED: A prospective observational study conducted over a 3-year period at a tertiary care paediatric surgery centre recruited 76 children with UDT undergoing surgical correction. Inhibin-B as a marker for Sertoli cell function was studied preoperatively and postoperatively. Continuous variables were summarised by calculating mean, standard deviation, median and interquartile range (IQR). Quantile versus quantile plotting was done to assess the distribution of the data. Data were analysed in two groups, with participants aged <2 years (Group A) and more than 2 years (Group B). Wilcoxon signed-rank test was used to compare the pre-operative and post-operative value.
UNASSIGNED: In Group A (n = 39), the median (IQR) of pre-operative inhibin-B was 181 pg/ml (148-254) and post-operative inhibin-B was 230 pg/ml (176-296). In Group B, the median (IQR) of pre-operative inhibin was 70 pg/ml (44-104) and post-operative inhibin was 102 pg/ml (46-176). There was a significant increase in post-operative inhibin when compared to the pre-operative inhibin (P = 0.015 and 0.012, respectively, in Group A and B). Luteinizing hormone (LH) showed a significant decrease (P = 0.002) in Group A following surgery but bordering on significance in Group B (P = 0.43). On the other hand, follicle-stimulating hormone showed a significant decrease (P < 0.01) in Group B following surgery but not in Group A (P = 0.87).
UNASSIGNED: The mean post-operative inhibin-B levels were increased significantly as compared to the pre-operative levels indicating either a successful orchiopexy/adequate germ cell number or both. The benefit of orchiopexy may extend even to children presenting late for evaluation.
UNASSIGNED: A prospective observational study conducted over a 3-year period at a tertiary care paediatric surgery centre recruited 76 children with UDT undergoing surgical correction. Inhibin-B as a marker for Sertoli cell function was studied preoperatively and postoperatively. Continuous variables were summarised by calculating mean, standard deviation, median and interquartile range (IQR). Quantile versus quantile plotting was done to assess the distribution of the data. Data were analysed in two groups, with participants aged <2 years (Group A) and more than 2 years (Group B). Wilcoxon signed-rank test was used to compare the pre-operative and post-operative value.
UNASSIGNED: In Group A (n = 39), the median (IQR) of pre-operative inhibin-B was 181 pg/ml (148-254) and post-operative inhibin-B was 230 pg/ml (176-296). In Group B, the median (IQR) of pre-operative inhibin was 70 pg/ml (44-104) and post-operative inhibin was 102 pg/ml (46-176). There was a significant increase in post-operative inhibin when compared to the pre-operative inhibin (P = 0.015 and 0.012, respectively, in Group A and B). Luteinizing hormone (LH) showed a significant decrease (P = 0.002) in Group A following surgery but bordering on significance in Group B (P = 0.43). On the other hand, follicle-stimulating hormone showed a significant decrease (P < 0.01) in Group B following surgery but not in Group A (P = 0.87).
UNASSIGNED: The mean post-operative inhibin-B levels were increased significantly as compared to the pre-operative levels indicating either a successful orchiopexy/adequate germ cell number or both. The benefit of orchiopexy may extend even to children presenting late for evaluation.
摘要：
未经证实：未降睾丸（UDT）或隐睾是一种常见的先天性残疾，其特征是阴囊中至少有一个睾丸缺失。手术矫正的主要目的是保持生育潜力并预防包括创伤在内的并发症。恶性肿瘤，疝气和扭转.通常,孩子们,特别是在发展中国家，与UDT一起迟到。手术矫正对2岁以上儿童支持细胞功能恢复的影响不明显。进行本研究是为了研究异质人群中手术校正的UDT中抑制素B水平作为支持细胞功能标志物的变化。
UNASSIGNED：一项在三级护理儿科手术中心进行的为期3年的前瞻性观察性研究招募了76名接受手术矫正的UDT儿童。术前和术后研究了抑制素B作为支持细胞功能的标志物。连续变量通过计算平均值来总结，标准偏差，中位数和四分位数间距（IQR）。进行分位数对分位数作图以评估数据的分布。对两组数据进行分析,参与者年龄<2岁（A组）和2岁以上（B组）。使用Wilcoxon符号秩检验比较术前和术后值。
未经批准：在A组（n=39）中，术前抑制素-B的中位数(IQR)为181pg/ml(148~254),术后抑制素-B为230pg/ml(176~296).B组,术前抑制素的中位数(IQR)为70pg/ml(44~104),术后抑制素为102pg/ml(46~176).术后抑制素与术前抑制素相比显著增加(P=0.015和0.012,A组和B组)。促黄体生成素（LH）在A组中显示出手术后的显着降低（P=0.002），但在B组中具有显著性（P=0.43）。另一方面,B组术后卵泡刺激素明显下降(P<0.01),A组无明显下降(P=0.87)。
UNASSIGNED：与手术前水平相比，术后抑制素B的平均水平显着增加，表明睾丸固定术成功/生殖细胞数量充足或两者兼而有之。睾丸固定术的好处甚至可以扩展到迟到评估的儿童。
UNASSIGNED：一项在三级护理儿科手术中心进行的为期3年的前瞻性观察性研究招募了76名接受手术矫正的UDT儿童。术前和术后研究了抑制素B作为支持细胞功能的标志物。连续变量通过计算平均值来总结，标准偏差，中位数和四分位数间距（IQR）。进行分位数对分位数作图以评估数据的分布。对两组数据进行分析,参与者年龄<2岁（A组）和2岁以上（B组）。使用Wilcoxon符号秩检验比较术前和术后值。
未经批准：在A组（n=39）中，术前抑制素-B的中位数(IQR)为181pg/ml(148~254),术后抑制素-B为230pg/ml(176~296).B组,术前抑制素的中位数(IQR)为70pg/ml(44~104),术后抑制素为102pg/ml(46~176).术后抑制素与术前抑制素相比显著增加(P=0.015和0.012,A组和B组)。促黄体生成素（LH）在A组中显示出手术后的显着降低（P=0.002），但在B组中具有显著性（P=0.43）。另一方面,B组术后卵泡刺激素明显下降(P<0.01),A组无明显下降(P=0.87)。
UNASSIGNED：与手术前水平相比，术后抑制素B的平均水平显着增加，表明睾丸固定术成功/生殖细胞数量充足或两者兼而有之。睾丸固定术的好处甚至可以扩展到迟到评估的儿童。
