Abstract：
Pluripotent stem cells (PSCs), which can self-renew and give rise to all cell types in all three germ layers, have great potential in regenerative medicine. Recent studies have shown that PSCs can have three distinct but interrelated pluripotent states: naive, formative, and primed. The PSCs of each state are derived from different stages of the early developing embryo and can be maintained in culture by different molecular mechanisms. In this review, we summarize the current understanding on features of the three pluripotent states and review the underlying molecular mechanisms of maintaining their identities. Lastly, we discuss the interrelation and transition among these pluripotency states. We believe that comprehending the divergence of pluripotent states is essential to fully harness the great potential of stem cells in regenerative medicine.
摘要：
多能干细胞（PSC），可以自我更新并在所有三个胚层中产生所有细胞类型，在再生医学方面有很大的潜力。最近的研究表明，PSC可以具有三种不同但相互关联的多能状态：形成性,和准备。每种状态的PSC源自早期发育胚胎的不同阶段，并且可以通过不同的分子机制维持在培养物中。在这次审查中,我们总结了目前对三种多能状态特征的理解，并回顾了维持其身份的潜在分子机制。最后,我们讨论了这些多能性状态之间的相互关系和过渡。我们认为，理解多能状态的差异对于充分利用干细胞在再生医学中的巨大潜力至关重要。
