PDF(Pubmed)
Abstract：
Postoperative neurocognitive disorder (PND) is a common postoperative complication, particularly in older patients. Electroencephalogram (EEG) monitoring, a non-invasive technique with a high spatial-temporal resolution, can accurately characterize the dynamic changes in brain function during the perioperative period. Current clinical studies have confirmed that the power density of alpha oscillation during general anesthesia decreased with age, which was considered to be associated with increased susceptibility to PND in the elderly. However, evidence on whether general anesthesia under EEG guidance results in a lower morbidity of PND is still contradictory. This is one of the reasons that common indicators of the depth of anesthesia were limitedly derived from EEG signals in the frontal lobe. The variation of multi-channel EEG features during the perioperative period has the potential to highlight the occult structural and functional abnormalities of the subcortical-cortical neurocircuit. Therefore, we present a review of the application of multi-channel EEG monitoring to predict the incidence of PND in older patients. The data confirmed that the abnormal variation in EEG power and functional connectivity between distant brain regions was closely related to the incidence and long-term poor outcomes of PND in older adults.
摘要：
术后神经认知障碍（PND）是一种常见的术后并发症，尤其是老年患者。脑电图（EEG）监测，一种具有高时空分辨率的非侵入性技术，能准确表征围手术期脑功能的动态变化。今朝的临床研讨证实，全身麻醉中α振荡的功率密度随年纪的增长而下降，这被认为与老年人对PND的易感性增加有关。然而,关于在EEG指导下全身麻醉是否降低PND发病率的证据仍然存在矛盾。这是麻醉深度的常见指标有限地来自额叶中的EEG信号的原因之一。围手术期多通道脑电图特征的变化有可能突出皮质下-皮质神经回路的隐匿性结构和功能异常。因此,我们对多通道脑电图监测在预测老年患者PND发病率中的应用进行了综述.数据证实，远隔脑区脑电图功率和功能连接的异常变化与老年人PND的发生率和长期不良结局密切相关。
