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Abstract：
UNASSIGNED: To evaluate the impact of severe tricuspid valve insufficiency (TVI) at the time of left ventricular assist device (LVAD) implantation on the hemodynamic and LVAD parameters in an acute ovine model.
UNASSIGNED: Stable heart failure (HF) was induced in 10 ovines through the application of 3 ± 1 coronary ligations. Once stable HF was obtained (after 15 ± 5 days), the animals were supported with an LVAD. Hemodynamic data and pump parameters were obtained and compared in 2 settings; first with LVAD in place after weaning from the cardiopulmonary bypass machine (no TVI condition) and second following the induction of severe TVI through resection of the tricuspid valve (TVI condition).
UNASSIGNED: There were no statistically significant differences in the hemodynamic and pump parameters between TVI condition and no TVI conditions except for lower cardiac output in the TVI condition (2 [1.38-2.8] L/min vs 3.2 [1.55-3.7] L/min, P = .027) and the expected greater central venous pressure in the TVI condition (26 [24-31] mm Hg vs 15 [13-25] mm Hg, P = .020). A median pump flow of 2.8 (2.45-3.75) L/min versus 2.9 (2.75-3.8) L/min in the TVI condition and no TVI condition was documented (P = .160).
UNASSIGNED: Results from this acute animal study suggest that severe TVI in HF with preserved right ventricular function does not have significant impact on the LVAD pump parameters. The observed reduction in cardiac output may warrant further investigations, especially under loading conditions.
UNASSIGNED: Stable heart failure (HF) was induced in 10 ovines through the application of 3 ± 1 coronary ligations. Once stable HF was obtained (after 15 ± 5 days), the animals were supported with an LVAD. Hemodynamic data and pump parameters were obtained and compared in 2 settings; first with LVAD in place after weaning from the cardiopulmonary bypass machine (no TVI condition) and second following the induction of severe TVI through resection of the tricuspid valve (TVI condition).
UNASSIGNED: There were no statistically significant differences in the hemodynamic and pump parameters between TVI condition and no TVI conditions except for lower cardiac output in the TVI condition (2 [1.38-2.8] L/min vs 3.2 [1.55-3.7] L/min, P = .027) and the expected greater central venous pressure in the TVI condition (26 [24-31] mm Hg vs 15 [13-25] mm Hg, P = .020). A median pump flow of 2.8 (2.45-3.75) L/min versus 2.9 (2.75-3.8) L/min in the TVI condition and no TVI condition was documented (P = .160).
UNASSIGNED: Results from this acute animal study suggest that severe TVI in HF with preserved right ventricular function does not have significant impact on the LVAD pump parameters. The observed reduction in cardiac output may warrant further investigations, especially under loading conditions.
摘要：
UNASSIGNED：评估急性绵羊模型中左心室辅助装置（LVAD）植入时严重三尖瓣关闭不全（TVI）对血液动力学和LVAD参数的影响。
UNASSIGNED：通过应用3±1个冠状动脉结扎，在10只绵羊中诱发了稳定型心力衰竭（HF）。一旦获得稳定的HF（15±5天后），用LVAD支持动物。在2种设置中获得并比较了血液动力学数据和泵参数；首先是在从体外循环机断奶后（无TVI条件）使用LVAD，其次是在通过切除三尖瓣（TVI条件）诱导严重TVI后使用LVAD。
UNASSIGNED：除了TVI条件下的较低心输出量外，TVI条件和无TVI条件之间的血流动力学和泵参数没有统计学上的显着差异（2[1.38-2.8]L/minvs3.2[1.55-3.7]L/min，P=.027）和TVI条件下预期的较高中心静脉压（26[24-31]mmHgvs15[13-25]mmHg，P=.020）。记录了在TVI条件和无TVI条件下的中值泵流量为2.8（2.45-3.75）L/min与2.9（2.75-3.8）L/min的对比（P=.160）。
UNASSIGNED：这项急性动物研究的结果表明，右心室功能保留的HF患者的严重TVI对LVAD泵参数没有显着影响。观察到的心输出量减少可能需要进一步研究，特别是在负载条件下。
UNASSIGNED：通过应用3±1个冠状动脉结扎，在10只绵羊中诱发了稳定型心力衰竭（HF）。一旦获得稳定的HF（15±5天后），用LVAD支持动物。在2种设置中获得并比较了血液动力学数据和泵参数；首先是在从体外循环机断奶后（无TVI条件）使用LVAD，其次是在通过切除三尖瓣（TVI条件）诱导严重TVI后使用LVAD。
UNASSIGNED：除了TVI条件下的较低心输出量外，TVI条件和无TVI条件之间的血流动力学和泵参数没有统计学上的显着差异（2[1.38-2.8]L/minvs3.2[1.55-3.7]L/min，P=.027）和TVI条件下预期的较高中心静脉压（26[24-31]mmHgvs15[13-25]mmHg，P=.020）。记录了在TVI条件和无TVI条件下的中值泵流量为2.8（2.45-3.75）L/min与2.9（2.75-3.8）L/min的对比（P=.160）。
UNASSIGNED：这项急性动物研究的结果表明，右心室功能保留的HF患者的严重TVI对LVAD泵参数没有显着影响。观察到的心输出量减少可能需要进一步研究，特别是在负载条件下。
