PDF(Pubmed)
Abstract：
UNASSIGNED: Statins have been shown to delay the inevitable progression of atherosclerosis in native coronaries and saphenous vein grafts, thereby reducing ischemic events after surgical coronary revascularization. However, there is significant controversy as to whether titrating statin therapy to concrete cholesterol targets is appropriate.
UNASSIGNED: A single-center retrospective analysis of 309 consecutive patients who underwent isolated coronary artery bypass graft in 2007 and 2008 was performed. Measurements of lipid profile subcomponents, namely total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides, in mmol/L, were obtained by retrospective review of electronic health records. The primary end point was cardiac death. The secondary end point was the composite of cardiac events, including cardiac death, nonfatal myocardial infarction, hospitalization for unstable angina, and target lesion revascularization. Database lock date was August 15, 2020.
UNASSIGNED: The median follow-up duration was 12.5 years. Cardiac death occurred in 6.8% of the cohort. Cardiac events occurred in 21.7% of the cohort. New-onset myocardial infarction occurred in 8.7% (n = 27), of which 48.1% (n = 13) underwent repeat revascularization. A 2-level nested Cox proportional hazards regression model was constructed to determine whether cholesterol target attainment was independently associated with cardiac events. After risk adjustment, LDL-C, non-HDL-C, total cholesterol (TC), and TC/HDL-C ratio were independently associated with cardiac death. In receiver operating characteristics analyses, the optimal cut-off values for non-HDL-C, LDL-C, and TC/HDL-C ratio were 3.2 mmol/L, 2.3 mmol/L, and 3.5, respectively.
UNASSIGNED: Exposure to elevated LDL-C and non-HDL-C cholesterol levels independently predicted long-term cardiac death after coronary artery bypass graft.
UNASSIGNED: A single-center retrospective analysis of 309 consecutive patients who underwent isolated coronary artery bypass graft in 2007 and 2008 was performed. Measurements of lipid profile subcomponents, namely total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides, in mmol/L, were obtained by retrospective review of electronic health records. The primary end point was cardiac death. The secondary end point was the composite of cardiac events, including cardiac death, nonfatal myocardial infarction, hospitalization for unstable angina, and target lesion revascularization. Database lock date was August 15, 2020.
UNASSIGNED: The median follow-up duration was 12.5 years. Cardiac death occurred in 6.8% of the cohort. Cardiac events occurred in 21.7% of the cohort. New-onset myocardial infarction occurred in 8.7% (n = 27), of which 48.1% (n = 13) underwent repeat revascularization. A 2-level nested Cox proportional hazards regression model was constructed to determine whether cholesterol target attainment was independently associated with cardiac events. After risk adjustment, LDL-C, non-HDL-C, total cholesterol (TC), and TC/HDL-C ratio were independently associated with cardiac death. In receiver operating characteristics analyses, the optimal cut-off values for non-HDL-C, LDL-C, and TC/HDL-C ratio were 3.2 mmol/L, 2.3 mmol/L, and 3.5, respectively.
UNASSIGNED: Exposure to elevated LDL-C and non-HDL-C cholesterol levels independently predicted long-term cardiac death after coronary artery bypass graft.
摘要：
未经证实：他汀类药物已被证明可延缓天然冠状动脉和隐静脉移植物中动脉粥样硬化的不可避免的进展，从而减少手术冠状动脉血运重建后的缺血事件。然而,对于针对具体的胆固醇目标滴定他汀类药物治疗是否合适,存在重大争议.
UNASSIGNED：对2007年和2008年接受孤立冠状动脉搭桥术的309例连续患者进行了单中心回顾性分析。脂质分布亚组分的测量，即总胆固醇，高密度脂蛋白胆固醇（HDL-C），低密度脂蛋白胆固醇（LDL-C），和甘油三酯，mmol/L,是通过对电子健康记录的回顾性审查获得的。主要终点是心脏死亡。次要终点是心脏事件的复合，包括心脏死亡,非致死性心肌梗死,不稳定型心绞痛住院,和靶病变血运重建。数据库锁定日期为2020年8月15日。
UNASSIGNED：中位随访时间为12.5年。6.8%的队列患者发生心源性死亡。21.7％的队列发生心脏事件。新发心肌梗死发生率为8.7%(n=27),其中48.1%(n=13)接受了重复血运重建。构建2水平嵌套Cox比例风险回归模型，以确定胆固醇目标是否与心脏事件独立相关。风险调整后，LDL-C,非HDL-C,总胆固醇(TC),TC/HDL-C比值与心源性死亡独立相关。在接收机工作特性分析中，非HDL-C的最佳截止值，LDL-C,TC/HDL-C比值为3.2mmol/L,2.3mmol/L,和3.5，分别。
UNASSIGNED：暴露于升高的LDL-C和非HDL-C胆固醇水平独立预测冠状动脉旁路移植术后的长期心脏死亡。
UNASSIGNED：对2007年和2008年接受孤立冠状动脉搭桥术的309例连续患者进行了单中心回顾性分析。脂质分布亚组分的测量，即总胆固醇，高密度脂蛋白胆固醇（HDL-C），低密度脂蛋白胆固醇（LDL-C），和甘油三酯，mmol/L,是通过对电子健康记录的回顾性审查获得的。主要终点是心脏死亡。次要终点是心脏事件的复合，包括心脏死亡,非致死性心肌梗死,不稳定型心绞痛住院,和靶病变血运重建。数据库锁定日期为2020年8月15日。
UNASSIGNED：中位随访时间为12.5年。6.8%的队列患者发生心源性死亡。21.7％的队列发生心脏事件。新发心肌梗死发生率为8.7%(n=27),其中48.1%(n=13)接受了重复血运重建。构建2水平嵌套Cox比例风险回归模型，以确定胆固醇目标是否与心脏事件独立相关。风险调整后，LDL-C,非HDL-C,总胆固醇(TC),TC/HDL-C比值与心源性死亡独立相关。在接收机工作特性分析中，非HDL-C的最佳截止值，LDL-C,TC/HDL-C比值为3.2mmol/L,2.3mmol/L,和3.5，分别。
UNASSIGNED：暴露于升高的LDL-C和非HDL-C胆固醇水平独立预测冠状动脉旁路移植术后的长期心脏死亡。
