Abstract：
To determine the impact of lower limb lymphoedema (LLL) on health-related quality of life (HRQoL), and to identify the methodologies used to assess HRQoL and their adherence to the World Health Organization (WHO)-recommended HRQoL dimensions.
A systematic review was used following the PRISMA guidance. Studies were eligible if they assessed HRQoL in adult patients with LLL. The search was conducted between September 2019 and February 2020 using CINAHL, PubMed, Scopus, EMBASE and the Cochrane Library database. Data were placed onto a pre-developed data extraction table and analysed using a narrative synthesis. Evidence-based Librarianship (EBL) was used for quality appraisal.
A total of 18 studies were identified, among which 10 were cross-sectional and eight were longitudinal studies. Twelve HRQoL questionnaires were identified and the Lymphoedema Quality of Life tool (LYMQoL) was the most commonly used. All of the studies except one had an EBL validity score of ≥75%. Although LLL causes a considerable impairment in HRQoL, the findings varied across the studies. All the studies considered at least four of the six WHO recommended dimensions, with none considering the spirituality dimension. Furthermore, physical functioning and wellbeing were discovered to be the worst affected HRQoL dimensions.
LLL adversely affects physical function, wellbeing and thus the HRQoL. The LYMQoL is the most commonly used questionnaire; despite this, all elements of the WHO recommendations were not captured in the included studies. However, accurate information on HRQoL indicating the impact of the disease on survivors\' lives and complete wellbeing is needed to inform evidence-based decision-making. Furthermore, having a universally accepted, disease-specific methodology will facilitate comparison and contrasting of HRQoL in patients with LLL.
The authors have no conflicts of interest.
A systematic review was used following the PRISMA guidance. Studies were eligible if they assessed HRQoL in adult patients with LLL. The search was conducted between September 2019 and February 2020 using CINAHL, PubMed, Scopus, EMBASE and the Cochrane Library database. Data were placed onto a pre-developed data extraction table and analysed using a narrative synthesis. Evidence-based Librarianship (EBL) was used for quality appraisal.
A total of 18 studies were identified, among which 10 were cross-sectional and eight were longitudinal studies. Twelve HRQoL questionnaires were identified and the Lymphoedema Quality of Life tool (LYMQoL) was the most commonly used. All of the studies except one had an EBL validity score of ≥75%. Although LLL causes a considerable impairment in HRQoL, the findings varied across the studies. All the studies considered at least four of the six WHO recommended dimensions, with none considering the spirituality dimension. Furthermore, physical functioning and wellbeing were discovered to be the worst affected HRQoL dimensions.
LLL adversely affects physical function, wellbeing and thus the HRQoL. The LYMQoL is the most commonly used questionnaire; despite this, all elements of the WHO recommendations were not captured in the included studies. However, accurate information on HRQoL indicating the impact of the disease on survivors\' lives and complete wellbeing is needed to inform evidence-based decision-making. Furthermore, having a universally accepted, disease-specific methodology will facilitate comparison and contrasting of HRQoL in patients with LLL.
The authors have no conflicts of interest.
摘要：
确定下肢淋巴水肿（LLL）对健康相关生活质量（HRQoL）的影响，并确定用于评估HRQoL及其对世界卫生组织（WHO）推荐的HRQoL维度的依从性的方法。
在PRISMA指导下进行了系统评价。如果研究评估了成人LLL患者的HRQoL，则研究合格。搜索是在2019年9月至2020年2月之间使用CINAHL进行的，PubMed,Scopus,EMBASE和Cochrane图书馆数据库。将数据放在预先开发的数据提取表上，并使用叙述性综合进行分析。循证图书馆学（EBL）用于质量评估。
总共确定了18项研究，其中10项为横断面研究,8项为纵向研究.确定了12份HRQoL问卷，最常用的是淋巴水肿生活质量工具（LYMQoL）。除一项研究外，所有研究的EBL有效性评分均≥75%。尽管LLL导致HRQoL相当大的损害，研究结果各不相同。所有研究都考虑了世卫组织推荐的六个维度中的至少四个，没有人考虑灵性维度。此外，发现身体功能和健康是受影响最严重的HRQoL维度。
LLL对身体功能产生不利影响，福祉，因此HRQoL。LYMQoL是最常用的问卷；尽管如此，纳入的研究未包含WHO建议的所有要素.然而,需要有关HRQoL的准确信息，以表明疾病对幸存者生活和完全健康的影响，以告知循证决策。此外，有一个普遍接受的，疾病特异性方法将有助于LLL患者HRQoL的比较和对比。
作者没有利益冲突。
在PRISMA指导下进行了系统评价。如果研究评估了成人LLL患者的HRQoL，则研究合格。搜索是在2019年9月至2020年2月之间使用CINAHL进行的，PubMed,Scopus,EMBASE和Cochrane图书馆数据库。将数据放在预先开发的数据提取表上，并使用叙述性综合进行分析。循证图书馆学（EBL）用于质量评估。
总共确定了18项研究，其中10项为横断面研究,8项为纵向研究.确定了12份HRQoL问卷，最常用的是淋巴水肿生活质量工具（LYMQoL）。除一项研究外，所有研究的EBL有效性评分均≥75%。尽管LLL导致HRQoL相当大的损害，研究结果各不相同。所有研究都考虑了世卫组织推荐的六个维度中的至少四个，没有人考虑灵性维度。此外，发现身体功能和健康是受影响最严重的HRQoL维度。
LLL对身体功能产生不利影响，福祉，因此HRQoL。LYMQoL是最常用的问卷；尽管如此，纳入的研究未包含WHO建议的所有要素.然而,需要有关HRQoL的准确信息，以表明疾病对幸存者生活和完全健康的影响，以告知循证决策。此外，有一个普遍接受的，疾病特异性方法将有助于LLL患者HRQoL的比较和对比。
作者没有利益冲突。
