关键词: Beta-thalassemia Beta-thalassémie Compression médullaire Extra medullary hematopoiesis Hématopoïèse extra médullaire Medullary compression Radiotherapy Radiothérapie

Mesh : Humans Adult Bone Marrow Re-Irradiation Hematopoiesis Radiation Oncology Palliative Care

来  源:   DOI:10.1016/j.canrad.2022.07.015

Abstract:
We present the case of a 40-year-old patient with β-Thalassemia major who underwent decompressive palliative radiotherapy on symptomatic intracanal extra medullary hematopoiesis on three occasions between 2016 and 2020. We delivered normo-fractionated radiotherapy at a dose of 10Gy in five fractions on vertebrae T4 to T10 and L3 to S2, 20Gy in ten fractions on vertebrae C7 to T11, and 12Gy in six fractions on vertebrae C7 to T9. The treatment was well tolerated with complete recovery of the symptomatology during the first two irradiations, and almost complete recovery after the 3rd irradiation.
摘要:
我们介绍了一名40岁的β-地中海贫血患者的病例,该患者在2016年至2020年之间三次接受了症状性肛门内髓外造血的姑息性放疗。我们在椎骨T4至T10和L3至S2的五个部分中以10Gy的剂量进行了正常分割的放射治疗,在椎骨C7至T11的十个部分中以20Gy,在椎骨C7至T9的六个部分中以12Gy的剂量进行了放射治疗。在前两次照射期间,治疗耐受性良好,症状完全恢复。第三次照射后几乎完全恢复。
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