METHODS: This observational cross-sectional study was conducted in 61 patients (60 women, one man, mean age 57.64 [13.52]) diagnosed of pSS according to the American-European Criteria (2002). After recording demographic, medical and dental data (decayed-missing-filled teeth index [DMFT]), unstimulated (UWS) and stimulated (SWS) salivary flows were collected. Subsequently, UWS flow was categorized into two groups (<0.1 ml/min and ≥0.1 ml/min) and SWS into three groups (<0.1 ml/min, 0.1-0.7 ml/min and >0.7 ml/min). Patients also filled out a visual analog scale (VAS) for xerostomia and OHIP-14 for self-reported quality of life (QoL).
RESULTS: Data showed positive and significant correlation between OHIP-14 and xerostomia, based on VAS results (r = 0.52; p = 0.001). Furthermore, there was a negative correlation between UWS and OHIP-14 scores (r = -0.34; p = 0.006) and VAS for xerostomia (r = -0.22; p = 0.09). No significant correlation was found between SWS and OHIP-14 or VAS neither between DMFT and OHIP-14. When assessing the level of QoL by the UWS and SWS flow categories a significant association was found for UWS (p = 0.001) but not for SWS (p = 0.11). The OHIP-14 values were higher in the groups with lower salivary flow. The multiple linear regression to predict OHIP-14 only selected VAS for xerostomia as a statistically significant predictor.
CONCLUSIONS: Increased level of xerostomia and reduced UWS flow decrease oral health-related QoL in patients with pSS.
方法:这项观察性横断面研究是在61名患者中进行的(60名女性,一个人,平均年龄57.64[13.52])根据美国-欧洲标准(2002年)诊断为pSS。记录人口统计信息后,医疗和牙科数据(腐烂缺失填充牙齿指数[DMFT]),收集未刺激(UWS)和刺激(SWS)的唾液流。随后,UWS流量分为两组(<0.1ml/min和≥0.1ml/min),SWS分为三组(<0.1ml/min,0.1-0.7ml/min和>0.7ml/min)。患者还填写了口干症的视觉模拟量表(VAS)和自我报告的生活质量(QoL)的OHIP-14。
结果:数据显示OHIP-14与口干症呈正相关,基于VAS结果(r=0.52;p=0.001)。此外,UWS和OHIP-14评分(r=-0.34;p=0.006)与口干症的VAS(r=-0.22;p=0.09)之间呈负相关。SWS与OHIP-14或VAS之间均未发现显着相关性。当通过UWS和SWS流量类别评估QoL水平时,发现UWS(p=0.001)而不是SWS(p=0.11)。唾液流量较低的组的OHIP-14值较高。预测OHIP-14的多元线性回归仅选择了口干症的VAS作为统计学上有意义的预测因子。
结论:在pSS患者中,口干症水平增加和UWS流量减少会降低与口腔健康相关的QoL。