Abstract：
BACKGROUND: The aim of this study is to analyze if the results of the Oral Health Impact Profile-14 questionnaire (OHIP-14) in patients with primary Sjögren\'s syndrome (pSS) are correlated with salivary flow and level of xerostomia.
METHODS: This observational cross-sectional study was conducted in 61 patients (60 women, one man, mean age 57.64 [13.52]) diagnosed of pSS according to the American-European Criteria (2002). After recording demographic, medical and dental data (decayed-missing-filled teeth index [DMFT]), unstimulated (UWS) and stimulated (SWS) salivary flows were collected. Subsequently, UWS flow was categorized into two groups (<0.1 ml/min and ≥0.1 ml/min) and SWS into three groups (<0.1 ml/min, 0.1-0.7 ml/min and >0.7 ml/min). Patients also filled out a visual analog scale (VAS) for xerostomia and OHIP-14 for self-reported quality of life (QoL).
RESULTS: Data showed positive and significant correlation between OHIP-14 and xerostomia, based on VAS results (r = 0.52; p = 0.001). Furthermore, there was a negative correlation between UWS and OHIP-14 scores (r = -0.34; p = 0.006) and VAS for xerostomia (r = -0.22; p = 0.09). No significant correlation was found between SWS and OHIP-14 or VAS neither between DMFT and OHIP-14. When assessing the level of QoL by the UWS and SWS flow categories a significant association was found for UWS (p = 0.001) but not for SWS (p = 0.11). The OHIP-14 values were higher in the groups with lower salivary flow. The multiple linear regression to predict OHIP-14 only selected VAS for xerostomia as a statistically significant predictor.
CONCLUSIONS: Increased level of xerostomia and reduced UWS flow decrease oral health-related QoL in patients with pSS.
METHODS: This observational cross-sectional study was conducted in 61 patients (60 women, one man, mean age 57.64 [13.52]) diagnosed of pSS according to the American-European Criteria (2002). After recording demographic, medical and dental data (decayed-missing-filled teeth index [DMFT]), unstimulated (UWS) and stimulated (SWS) salivary flows were collected. Subsequently, UWS flow was categorized into two groups (<0.1 ml/min and ≥0.1 ml/min) and SWS into three groups (<0.1 ml/min, 0.1-0.7 ml/min and >0.7 ml/min). Patients also filled out a visual analog scale (VAS) for xerostomia and OHIP-14 for self-reported quality of life (QoL).
RESULTS: Data showed positive and significant correlation between OHIP-14 and xerostomia, based on VAS results (r = 0.52; p = 0.001). Furthermore, there was a negative correlation between UWS and OHIP-14 scores (r = -0.34; p = 0.006) and VAS for xerostomia (r = -0.22; p = 0.09). No significant correlation was found between SWS and OHIP-14 or VAS neither between DMFT and OHIP-14. When assessing the level of QoL by the UWS and SWS flow categories a significant association was found for UWS (p = 0.001) but not for SWS (p = 0.11). The OHIP-14 values were higher in the groups with lower salivary flow. The multiple linear regression to predict OHIP-14 only selected VAS for xerostomia as a statistically significant predictor.
CONCLUSIONS: Increased level of xerostomia and reduced UWS flow decrease oral health-related QoL in patients with pSS.
摘要：
背景：本研究的目的是分析原发性干燥综合征（pSS）患者的口腔健康影响概况-14问卷（OHIP-14）的结果是否与唾液流量和口干症水平相关。
方法：这项观察性横断面研究是在61名患者中进行的（60名女性，一个人,平均年龄57.64[13.52]）根据美国-欧洲标准（2002年）诊断为pSS。记录人口统计信息后，医疗和牙科数据(腐烂缺失填充牙齿指数[DMFT])，收集未刺激（UWS）和刺激（SWS）的唾液流。随后，UWS流量分为两组（<0.1ml/min和≥0.1ml/min），SWS分为三组（<0.1ml/min，0.1-0.7ml/min和>0.7ml/min)。患者还填写了口干症的视觉模拟量表（VAS）和自我报告的生活质量（QoL）的OHIP-14。
结果：数据显示OHIP-14与口干症呈正相关，基于VAS结果(r=0.52；p=0.001)。此外，UWS和OHIP-14评分（r=-0.34;p=0.006）与口干症的VAS（r=-0.22;p=0.09）之间呈负相关。SWS与OHIP-14或VAS之间均未发现显着相关性。当通过UWS和SWS流量类别评估QoL水平时，发现UWS（p=0.001）而不是SWS（p=0.11）。唾液流量较低的组的OHIP-14值较高。预测OHIP-14的多元线性回归仅选择了口干症的VAS作为统计学上有意义的预测因子。
结论：在pSS患者中，口干症水平增加和UWS流量减少会降低与口腔健康相关的QoL。
方法：这项观察性横断面研究是在61名患者中进行的（60名女性，一个人,平均年龄57.64[13.52]）根据美国-欧洲标准（2002年）诊断为pSS。记录人口统计信息后，医疗和牙科数据(腐烂缺失填充牙齿指数[DMFT])，收集未刺激（UWS）和刺激（SWS）的唾液流。随后，UWS流量分为两组（<0.1ml/min和≥0.1ml/min），SWS分为三组（<0.1ml/min，0.1-0.7ml/min和>0.7ml/min)。患者还填写了口干症的视觉模拟量表（VAS）和自我报告的生活质量（QoL）的OHIP-14。
结果：数据显示OHIP-14与口干症呈正相关，基于VAS结果(r=0.52；p=0.001)。此外，UWS和OHIP-14评分（r=-0.34;p=0.006）与口干症的VAS（r=-0.22;p=0.09）之间呈负相关。SWS与OHIP-14或VAS之间均未发现显着相关性。当通过UWS和SWS流量类别评估QoL水平时，发现UWS（p=0.001）而不是SWS（p=0.11）。唾液流量较低的组的OHIP-14值较高。预测OHIP-14的多元线性回归仅选择了口干症的VAS作为统计学上有意义的预测因子。
结论：在pSS患者中，口干症水平增加和UWS流量减少会降低与口腔健康相关的QoL。
