PDF(Pubmed)
Abstract：
BACKGROUND: Pulmonary Langerhans cell histiocytosis (PLCH) is a rare cystic lung disease usually affecting young adults. It is predicted that PLCH is a lung tumor precursor associated with dysfunction of the myeloid dendritic cells in the lung.
METHODS: A 70-year-old male patient presented with chronic cough and sputum. He had symptoms for 5 years and described shortness of breath on exertion for the previous 3 years. He had a 60 packs/year smoking history. Computerized tomography of the thorax revealed an 11-mm nodule in the right lung lower lobe superior segment and a 7-mm nodule in the right lung lower lobe poster basal segment. Those two nodules were resected by means of right thoracoscopic surgery. Pathological evaluation revealed a squamous cell carcinoma and PLCH.
CONCLUSIONS: Coexistent squamous cell carcinoma and PLCH suggest possible association between PLCH and lung cancer.
METHODS: A 70-year-old male patient presented with chronic cough and sputum. He had symptoms for 5 years and described shortness of breath on exertion for the previous 3 years. He had a 60 packs/year smoking history. Computerized tomography of the thorax revealed an 11-mm nodule in the right lung lower lobe superior segment and a 7-mm nodule in the right lung lower lobe poster basal segment. Those two nodules were resected by means of right thoracoscopic surgery. Pathological evaluation revealed a squamous cell carcinoma and PLCH.
CONCLUSIONS: Coexistent squamous cell carcinoma and PLCH suggest possible association between PLCH and lung cancer.
摘要：
背景：肺朗格汉斯细胞组织细胞增生症（PLCH）是一种罕见的囊性肺病，通常会影响年轻人。预测PLCH是与肺中的骨髓性树突状细胞的功能障碍相关的肺肿瘤前体。
方法：一名70岁男性患者，表现为慢性咳嗽和痰。他有5年的症状，并描述了前3年劳累时呼吸急促。他有60包/年的吸烟史。胸部计算机断层扫描显示右肺下叶上段有11毫米结节，右肺下叶基底段有7毫米结节。通过右胸腔镜手术切除了这两个结节。病理评估显示鳞状细胞癌和PLCH。
结论：鳞状细胞癌和PLCH共存提示PLCH与肺癌之间可能存在关联。
方法：一名70岁男性患者，表现为慢性咳嗽和痰。他有5年的症状，并描述了前3年劳累时呼吸急促。他有60包/年的吸烟史。胸部计算机断层扫描显示右肺下叶上段有11毫米结节，右肺下叶基底段有7毫米结节。通过右胸腔镜手术切除了这两个结节。病理评估显示鳞状细胞癌和PLCH。
结论：鳞状细胞癌和PLCH共存提示PLCH与肺癌之间可能存在关联。
