Abstract：
A number of studies suggest that meteorological conditions are related to the risk of Legionnaires\' disease (LD) but the findings are not consistent. A systematic review was conducted to investigate the association of weather with sporadic LD and highlight the key meteorological conditions related to this outcome. PubMed, EMBASE, The Cochrane Library and OpenGrey were searched on 26-27 March 2020 without date, language or location restrictions. Key words included \"legionellosis\", \"legionnaires\' disease\", combined with \"meteorological conditions\", \"weather\", \"temperature\", \"humidity\", \"rain\", \"ultraviolet rays\", \"wind speed\", etc. Studies were excluded if they did not examine the exposure of interest, the outcome of interest and their association or if they only reported LD outbreak cases. The study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and it was registered in PROSPERO (#CRD42020168869). There were 811 articles, of which 17 were included in the review. The studies investigated different meteorological variables and most of them examined the combined effect of several variables. The most commonly examined factors were precipitation and temperature, followed by relative humidity. The studies suggested that increased precipitation, temperature and relative humidity were positively associated with the incidence of LD. There was limited evidence that higher wind speed, pressure, visibility, UV radiation and longer sunshine duration were inversely linked with the occurrence of LD. A period of increased but not very high temperatures, followed by a period of increased precipitation, favour the occurrence of LD. Increased awareness of the association of temperature and precipitation and LD occurrence among clinicians and public health professionals can improve differential diagnosis for cases of sporadic community-acquired pneumonia and at the same time contribute to improving LD surveillance.
摘要：
许多研究表明，气象条件与军团病（LD）的风险有关，但研究结果并不一致。进行了系统评价，以调查天气与零星LD的关系，并强调与此结果相关的关键气象条件。PubMed,EMBASE,Cochrane图书馆和OpenGrey于2020年3月26日至27日进行了搜索，没有日期，语言或位置限制。关键词包括“军团菌病”，“军团病”，结合“气象条件”，\"天气\",\"温度\",\"湿度\",\"雨\",\"紫外线\",“风速”，等。如果研究没有检查感兴趣的暴露，感兴趣的结果及其关联，或者他们只报告了LD爆发病例。该研究是根据系统评价和荟萃分析（PRISMA）指南的首选报告项目进行的，并在PROSPERO（＃CRD42020168869）中注册。有811篇文章，其中17人被列入审查范围。这些研究调查了不同的气象变量，其中大多数研究了几个变量的综合影响。最常检查的因素是降水和温度，其次是相对湿度。研究表明，降水增加，温度和相对湿度与LD的发生率呈正相关。有限的证据表明更高的风速，压力,可见性,紫外线辐射和更长的日照时间与LD的发生成反比。一段温度升高但不是很高的时期，随后是降水增加的时期，赞成LD的发生。提高临床医生和公共卫生专业人员对温度和降水与LD发生的关联的认识可以改善散发性社区获得性肺炎病例的鉴别诊断，同时有助于改善LD监测。
