PDF(Pubmed)
Abstract：
Cholangiocarcinoma (CCA), a neoplasm burdened by a poor prognosis and currently lacking adequate therapeutic treatments, can originate at different levels of the biliary tree, in the intrahepatic, hilar, or extrahepatic area. The main risk factors for the development of CCA are the presence of chronic cholangiopathies of various etiology. To date, the most studied prodromal diseases of CCA are primary sclerosing cholangitis, Caroli\'s disease and fluke infestations, but other conditions, such as metabolic syndrome, nonalcoholic fatty liver disease and obesity, are emerging as associated with an increased risk of CCA development. In this review, we focused on the analysis of the pro-inflammatory mechanisms that induce the development of CCA and on the role of cells of the immune response in cholangiocarcinogenesis. In very recent times, these cellular mechanisms have been the subject of emerging studies aimed at verifying how the modulation of the inflammatory and immunological responses can have a therapeutic significance and how these can be used as therapeutic targets.
摘要：
胆管癌（CCA），一种预后不良且目前缺乏适当治疗方法的肿瘤，可以起源于胆道树的不同层次，在肝内，hilar,或肝外区域。CCA发展的主要危险因素是各种病因的慢性胆管病变的存在。迄今为止,研究最多的CCA前驱疾病是原发性硬化性胆管炎，Caroli的疾病和吸虫感染,但是其他条件，比如代谢综合征，非酒精性脂肪性肝病和肥胖症，正在出现与CCA发展风险增加有关的情况。在这次审查中,我们重点分析了诱导CCA发展的促炎机制,以及免疫应答细胞在胆管癌发生中的作用.最近，这些细胞机制一直是新兴研究的主题，旨在验证炎症和免疫反应的调节如何具有治疗意义，以及如何将其用作治疗靶标。
