Abstract：
The Zika virus was responsible for an outbreak between 2015 and 2016 in Brazil: an alarming public health problem of international relevance. The Congenital Zika Syndrome (CZS) is often associated with manifestations that are responsible for cognitive and motor development delays and behavioral disorders. Thus, we aimed to characterize the clinical-epidemiological and familial context of those children and to identify factors associated with the risk of behavioral disorders using the Survey of Well-Being of Young Children questionnaire (SWYC). In total, 52 children diagnosed with CZS were evaluated. Logistic regressions were employed to assess predictive variables for behavioral alteration. Eighteen (35%) of the children presented a risk of behavioral alteration. Children born normocephalic were 36-fold more likely to present behavioral alteration (95% CI: 3.82 to 337.92, p = 0.002). Children with hearing and visual impairments showed reduced risks. In total, 35% percent of families reported food insecurity and 21% were at risk for maternal depression. Our findings suggest better social interactions and conditions to externalize reactions for children with CZS born normocephalic. The continuous assessment of these children and families may identify conditions associated with behavioral alteration and psychosocial vulnerabilities that help in decision-making, therefore optimizing patient-family interactions.
摘要：
寨卡病毒是2015年至2016年巴西爆发的原因：一个令人担忧的国际公共卫生问题。先天性寨卡综合症（CZS）通常与导致认知和运动发育迟缓和行为障碍的表现有关。因此，我们的目标是描述这些儿童的临床流行病学和家族背景,并使用幼儿幸福感调查问卷(SWYC)确定与行为障碍风险相关的因素.总的来说,对52例诊断为CZS的儿童进行了评估。Logistic回归用于评估行为改变的预测变量。18名（35％）的儿童存在行为改变的风险。出生时头颅正常的儿童出现行为改变的可能性高36倍（95％CI：3.82至337.92，p=0.002）。有听力和视力障碍的儿童表现出降低的风险。总的来说,35%的家庭报告粮食不安全，21%的家庭面临孕产妇抑郁症的风险。我们的发现表明，更好的社交互动和条件可以使出生正常的CZS儿童的反应外化。对这些儿童和家庭的持续评估可以确定与行为改变和心理社会脆弱性相关的条件，这有助于决策，因此，优化患者与家庭的互动。
