Abstract：
To detect eNOS gene polymorphism and its relation to cardiovascular complications in pediatric acute lymphoblastic leukemia (ALL) survivors.
CBC, renal and liver function tests, lipid profile, Carotid artery Intima Media Thickness (CIMT), and Brachial artery Intima Media Thickness (BIMT). eNOS gene polymorphism was done in 40 childhood ALL survivors and 40 controls.
There was no significant difference between survivors and control groups regarding 786 T/C polymorphism. There was a significant increase in serum cholesterol, TGs, LDL, VLDL, and HbA1c in the TC and CC group more than in the TT group, while there was a significant decrease in serum HDL in the TC and CC group more than in the TT group. There was no significant difference as regards echocardiography findings between different polymorphisms of 786 T/C, but there was a significant difference between 786 T/C groups with regard to the carotid and brachial arteries intima media thickness (IMT) measurements being significantly higher in the TC and CC group more than in the TT group.
Carotid and brachial arteries intima media thickness measurements were higher in the survivors when compared to healthy controls. eNOS gene polymorphism may play a role in modifying or developing CVD in pediatric ALL survivors.
CBC, renal and liver function tests, lipid profile, Carotid artery Intima Media Thickness (CIMT), and Brachial artery Intima Media Thickness (BIMT). eNOS gene polymorphism was done in 40 childhood ALL survivors and 40 controls.
There was no significant difference between survivors and control groups regarding 786 T/C polymorphism. There was a significant increase in serum cholesterol, TGs, LDL, VLDL, and HbA1c in the TC and CC group more than in the TT group, while there was a significant decrease in serum HDL in the TC and CC group more than in the TT group. There was no significant difference as regards echocardiography findings between different polymorphisms of 786 T/C, but there was a significant difference between 786 T/C groups with regard to the carotid and brachial arteries intima media thickness (IMT) measurements being significantly higher in the TC and CC group more than in the TT group.
Carotid and brachial arteries intima media thickness measurements were higher in the survivors when compared to healthy controls. eNOS gene polymorphism may play a role in modifying or developing CVD in pediatric ALL survivors.
摘要：
检测小儿急性淋巴细胞白血病（ALL）幸存者eNOS基因多态性及其与心血管并发症的关系。
CBC,肾和肝功能测试，血脂谱,颈动脉内膜中膜厚度(CIMT),和肱动脉内膜中膜厚度（BIMT）。eNOS基因多态性在40名儿童ALL幸存者和40名对照中进行。
786T/C多态性在存活组和对照组之间没有显着差异。血清胆固醇显著升高,TG,LDL,VLDL,TC和CC组的HbA1c高于TT组，而TC和CC组的血清HDL明显低于TT组。786T/C的不同多态性之间的超声心动图检查结果没有显着差异，但是786T/C组之间的颈动脉和肱动脉内膜中层厚度（IMT）测量值存在显着差异，TC和CC组明显高于TT组。
与健康对照组相比，幸存者的颈动脉和肱动脉内膜中层厚度测量值较高。eNOS基因多态性可能在改变或发展小儿ALL幸存者的CVD中起作用。
CBC,肾和肝功能测试，血脂谱,颈动脉内膜中膜厚度(CIMT),和肱动脉内膜中膜厚度（BIMT）。eNOS基因多态性在40名儿童ALL幸存者和40名对照中进行。
786T/C多态性在存活组和对照组之间没有显着差异。血清胆固醇显著升高,TG,LDL,VLDL,TC和CC组的HbA1c高于TT组，而TC和CC组的血清HDL明显低于TT组。786T/C的不同多态性之间的超声心动图检查结果没有显着差异，但是786T/C组之间的颈动脉和肱动脉内膜中层厚度（IMT）测量值存在显着差异，TC和CC组明显高于TT组。
与健康对照组相比，幸存者的颈动脉和肱动脉内膜中层厚度测量值较高。eNOS基因多态性可能在改变或发展小儿ALL幸存者的CVD中起作用。
