Abstract：
BACKGROUND: Bacterial skin infections and scabies disproportionately affect children in resource-poor countries as well as underprivileged children in high-income countries. Atopic dermatitis is a common childhood dermatosis that predisposes to bacterial skin infection. In Australia, at any one time, almost half of all Aboriginal and Torres Strait Islander children living remotely will have impetigo, and up to one-third will also have scabies. Yet, there is a gap in knowledge of the skin infection burden for urban-living Australian Aboriginal and Torres Strait Islander children, as well as atopic dermatitis which may be a contributing factor. The objective of this study is to provide a global background on the burden of these disorders in Indigenous urban-living children in high-income countries. These countries share a similar history of colonisation, dispossession and subsequent ongoing negative impacts on Indigenous people.
METHODS: This protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analyses Protocols statement. Observational studies reporting incidence and/or prevalence data on bacterial skin infection, scabies and/or atopic dermatitis in urban-living Indigenous children in high-income countries will be included. Literature searches will be conducted in several international electronic databases (from 1990 onwards), including MEDLINE, Embase, EmCare, Web of Science and PubMed. Reference lists and citation records of all included articles will be scanned for additional relevant manuscripts. Two investigators will independently perform eligibility assessment of titles, abstract and full-text manuscripts, following which both investigators will independently extract data. Where there is disagreement, the senior author will determine eligibility. The methodological quality of selected studies will be appraised using an appropriate tool. Data will be tabulated and narratively synthesised. We expect there will be insufficient data to perform meta-analysis.
CONCLUSIONS: This study will identify and evaluate epidemiological data on bacterial skin infection, scabies and atopic dermatitis in urban-living Indigenous children in high-income countries. Where available, the clinical features, risk factors, comorbidities and complications of these common childhood skin disorders will be described. The evidence will highlight the burden of disease in this population, to contribute to global burden of disease estimates and identify gaps in the current literature to provide direction for future research.
BACKGROUND: PROSPERO CRD42021277288.
METHODS: This protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analyses Protocols statement. Observational studies reporting incidence and/or prevalence data on bacterial skin infection, scabies and/or atopic dermatitis in urban-living Indigenous children in high-income countries will be included. Literature searches will be conducted in several international electronic databases (from 1990 onwards), including MEDLINE, Embase, EmCare, Web of Science and PubMed. Reference lists and citation records of all included articles will be scanned for additional relevant manuscripts. Two investigators will independently perform eligibility assessment of titles, abstract and full-text manuscripts, following which both investigators will independently extract data. Where there is disagreement, the senior author will determine eligibility. The methodological quality of selected studies will be appraised using an appropriate tool. Data will be tabulated and narratively synthesised. We expect there will be insufficient data to perform meta-analysis.
CONCLUSIONS: This study will identify and evaluate epidemiological data on bacterial skin infection, scabies and atopic dermatitis in urban-living Indigenous children in high-income countries. Where available, the clinical features, risk factors, comorbidities and complications of these common childhood skin disorders will be described. The evidence will highlight the burden of disease in this population, to contribute to global burden of disease estimates and identify gaps in the current literature to provide direction for future research.
BACKGROUND: PROSPERO CRD42021277288.
摘要：
背景：细菌性皮肤感染和sc疮不成比例地影响资源贫乏国家的儿童以及高收入国家的贫困儿童。特应性皮炎是一种常见的儿童皮肤病，易发生细菌性皮肤感染。在澳大利亚,在任何时候,几乎一半居住在偏远地方的原住民和托雷斯海峡岛民儿童会患有脓疱疮，多达三分之一的人也会有疮。然而，在城市生活的澳大利亚原住民和托雷斯海峡岛民儿童对皮肤感染负担的认识存在差距，以及特应性皮炎，这可能是一个促成因素。这项研究的目的是为高收入国家的土著城市儿童提供这些疾病负担的全球背景。这些国家有着相似的殖民历史，剥夺和随后对土著人民的持续负面影响。
方法：本方案遵循系统评价和荟萃分析的首选报告项目方案声明。报告细菌性皮肤感染发生率和/或患病率数据的观察性研究，将包括高收入国家城市土著儿童的sc疮和/或特应性皮炎。文献检索将在几个国际电子数据库中进行(从1990年起),包括MEDLINE,Embase,EmCare,WebofScience和PubMed。将扫描所有收录文章的参考列表和引用记录，以查找其他相关手稿。两名调查员将独立进行职称资格评估，摘要和全文手稿，随后，两位研究者将独立提取数据。哪里有分歧，资深作者将确定资格。将使用适当的工具评估选定研究的方法学质量。数据将被制表和叙述地综合。我们预计将没有足够的数据进行荟萃分析。
结论：本研究将确定和评估细菌性皮肤感染的流行病学数据，高收入国家的城市土著儿童的sc疮和特应性皮炎。如有,临床特征，危险因素，将描述这些常见的儿童皮肤病的合并症和并发症。证据将凸显这一人群的疾病负担，有助于估计全球疾病负担，并确定当前文献中的差距，为未来的研究提供方向。
背景：PROSPEROCRD42021277288。
方法：本方案遵循系统评价和荟萃分析的首选报告项目方案声明。报告细菌性皮肤感染发生率和/或患病率数据的观察性研究，将包括高收入国家城市土著儿童的sc疮和/或特应性皮炎。文献检索将在几个国际电子数据库中进行(从1990年起),包括MEDLINE,Embase,EmCare,WebofScience和PubMed。将扫描所有收录文章的参考列表和引用记录，以查找其他相关手稿。两名调查员将独立进行职称资格评估，摘要和全文手稿，随后，两位研究者将独立提取数据。哪里有分歧，资深作者将确定资格。将使用适当的工具评估选定研究的方法学质量。数据将被制表和叙述地综合。我们预计将没有足够的数据进行荟萃分析。
结论：本研究将确定和评估细菌性皮肤感染的流行病学数据，高收入国家的城市土著儿童的sc疮和特应性皮炎。如有,临床特征，危险因素，将描述这些常见的儿童皮肤病的合并症和并发症。证据将凸显这一人群的疾病负担，有助于估计全球疾病负担，并确定当前文献中的差距，为未来的研究提供方向。
背景：PROSPEROCRD42021277288。
