Abstract：
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).
This article has been retracted at the request of the Editor-in-Chief.
After a thorough investigation, the Editor has concluded that the acceptance of this article was partly based upon the positive advice of one illegitimate reviewer report. The report was submitted from an email account which was provided to the journal as a suggested reviewer during the submission of the article. Although purportedly a real reviewer account, the Editor has concluded that this was not of an appropriate, independent reviewer.
Further inquiry revealed that the name of the author Anshoo Malhotra was added after the acceptance of the article without notifying the author and the handling Editor, which is contrary to the journal policy on changes to authorship.
This manipulation of the peer-review process represents a clear violation of the fundamentals of peer review, our publishing policies, and publishing ethics standards. Apologies are offered to the reviewer whose identity was assumed and to the readers of the journal that this deception was not detected during the submission process.
摘要：
铁凋亡对肿瘤生长抑制至关重要。此外，铁性凋亡被认为是一种潜在的抗癌策略。本研究主要针对β-榄香烯在肺癌中诱导铁凋亡的机制进行研究。CCK-8测定，流式细胞术和生化测定，包括细胞内ROS，MDA,GSH,铁和8-OHdG水平进行。利用蛋白质印迹法研究了DNA聚合酶ε亚基2（Pole2）和铁凋亡相关蛋白。研究结果表明，β-榄香烯通过铁凋亡降低肺癌细胞的活力。此外，多个实验证实，Pole2敲除增强脂质ROS的产生，MDA和铁，导致肺癌细胞铁依赖的铁凋亡。Pole2的过表达通过减少铁依赖性氧化损伤来抑制β-榄香烯诱导的铁凋亡。机械上,Pole2降低了p53表达的上调，并增加β-榄香烯诱导细胞中PI3K和AKT的磷酸化水平。TP53的过表达或PI3K/AKT通路的抑制剂逆转了Pole2的作用。一起,β-榄香烯通过Pole2调节的p53或PI3K/AKT信号引起铁凋亡，可能是肺癌发生的有效疗法。
