Abstract：
The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs. This article addresses neuropathological changes associated with seizures and epilepsy in rodent models of epilepsy. We discuss CDEs for histopathological parameters for neurodegeneration, changes in astrocyte morphology and function, mechanisms of inflammation, and changes in the blood-brain barrier and myelin/oligodendrocytes resulting from recurrent seizures in rats and mice. We provide detailed CDE tables and case report forms (CRFs), and with this companion manuscript, we discuss the rationale and methodological aspects of individual neuropathological examinations. The CDEs, CRFs, and companion paper are available to all researchers, and their use will benefit the harmonization and comparability of translational preclinical epilepsy research. The ultimate hope is to facilitate the development of rational therapy concepts for treating epilepsies, seizures, and comorbidities and the development of biomarkers assessing the pathological state of the disease.
摘要：
国际抗癫痫联盟/美国癫痫学会（ILAE/AES）联合转化工作组发起了TASK3工作组，为临床前癫痫研究的各个方面创建通用数据元素（CDE）。这可以帮助提高实验设计的标准化。本文讨论了啮齿动物癫痫模型中与癫痫发作和癫痫相关的神经病理变化。我们讨论CDE用于神经变性的组织病理学参数，星形胶质细胞形态和功能的变化，炎症的机制，以及大鼠和小鼠反复发作导致的血脑屏障和髓磷脂/少突胶质细胞的变化。我们提供详细的CDE表和病例报告表(CRF)，有了这份伴随的手稿，我们讨论了个别神经病理学检查的基本原理和方法学方面。CDEs,CRFs,所有研究人员都可以获得配套论文，它们的使用将有利于转化性临床前癫痫研究的协调性和可比性。最终的希望是促进治疗癫痫的理性治疗概念的发展，癫痫发作,和合并症以及评估疾病病理状态的生物标志物的发展。
