Abstract：
OBJECTIVE: Amelogenesis imperfecta (AI) is a hereditary condition which affects the composition and structure of enamel in terms of hypoplasia and/or hypomineralization. The condition severely affects patients facing such difficulties as hypersensibility, loss of tooth substance and poor aesthetics. The objective is to perform a systematic review of patient-reported outcome measures (PROMs) in patients with amelogenesis imperfecta.
METHODS: Inclusion criteria were articles written in English, including PROMs from patients with amelogenesis imperfecta. The databases PubMed, Scopus and Web of Science were searched on April 27, 2022, and eligible articles were screened. Exclusion criteria were articles based on proxy reports and single case reports.
RESULTS: 405 studies were screened in terms of title and abstract, with 31 articles eligible for full-text screening, resulting in a total of 11 articles eligible for inclusion, (articles including 4-82 patients). The content was analyzed, resulting in the outcome divided into seven domains: Oral Health-Related Quality of Life (OHRQoL), Dental fear, Esthetics, Psychosocial factors, Function, Dental hypersensitivity, and Treatment outcome.
CONCLUSIONS: The limited quantity of research on PROMS from patients with AI indicates a significant impact of OHRQoL and daily life. A large variety of approaches have been presented in the articles. Patients report concerns of esthetics, hypersensitivity, function, and a general impact on well-being and social interaction. This highlights the importance for the need of early dental treatment.
UNASSIGNED: 256875.
METHODS: Inclusion criteria were articles written in English, including PROMs from patients with amelogenesis imperfecta. The databases PubMed, Scopus and Web of Science were searched on April 27, 2022, and eligible articles were screened. Exclusion criteria were articles based on proxy reports and single case reports.
RESULTS: 405 studies were screened in terms of title and abstract, with 31 articles eligible for full-text screening, resulting in a total of 11 articles eligible for inclusion, (articles including 4-82 patients). The content was analyzed, resulting in the outcome divided into seven domains: Oral Health-Related Quality of Life (OHRQoL), Dental fear, Esthetics, Psychosocial factors, Function, Dental hypersensitivity, and Treatment outcome.
CONCLUSIONS: The limited quantity of research on PROMS from patients with AI indicates a significant impact of OHRQoL and daily life. A large variety of approaches have been presented in the articles. Patients report concerns of esthetics, hypersensitivity, function, and a general impact on well-being and social interaction. This highlights the importance for the need of early dental treatment.
UNASSIGNED: 256875.
摘要：
目的：成釉细胞不全症（AI）是一种遗传性疾病，在发育不全和/或矿化不足方面影响牙釉质的组成和结构。这种情况严重影响了面临诸如高敏感性等困难的患者，牙齿物质的损失和不良的美学。目的是对牙釉质不全症患者的患者报告结局指标（PROMs）进行系统评价。
方法：纳入标准是用英语写的文章，包括牙釉质发育不全患者的PROMs。数据库PubMed,在2022年4月27日搜索了Scopus和WebofScience，并筛选了符合条件的文章。排除标准是基于代理报告和单个病例报告的文章。
结果：根据标题和摘要筛选了405项研究，有31篇文章符合全文筛选的条件，总共有11篇文章符合纳入条件，（文章包括4-82名患者）。对内容进行了分析，结果分为七个领域：口腔健康相关生活质量（OHRQoL），牙科恐惧，美学,社会心理因素,Function,牙科过敏，和治疗结果。
结论：AI患者对PROMS的研究数量有限，表明OHRQoL和日常生活有显著影响。在文章中提出了各种各样的方法。患者报告对美学的担忧，超敏反应，函数,以及对福祉和社交互动的普遍影响。这凸显了早期牙科治疗的重要性。
UNASSIGNED：256875。
方法：纳入标准是用英语写的文章，包括牙釉质发育不全患者的PROMs。数据库PubMed,在2022年4月27日搜索了Scopus和WebofScience，并筛选了符合条件的文章。排除标准是基于代理报告和单个病例报告的文章。
结果：根据标题和摘要筛选了405项研究，有31篇文章符合全文筛选的条件，总共有11篇文章符合纳入条件，（文章包括4-82名患者）。对内容进行了分析，结果分为七个领域：口腔健康相关生活质量（OHRQoL），牙科恐惧，美学,社会心理因素,Function,牙科过敏，和治疗结果。
结论：AI患者对PROMS的研究数量有限，表明OHRQoL和日常生活有显著影响。在文章中提出了各种各样的方法。患者报告对美学的担忧，超敏反应，函数,以及对福祉和社交互动的普遍影响。这凸显了早期牙科治疗的重要性。
UNASSIGNED：256875。
