Abstract：
Nowadays, an increased interest in natural compounds with preventive or therapeutic potential for various diseases has been observed. Given the involvement of oxidative stress in the pathogenesis of gastric ulcer (GU) and the wide range of bioactive compounds isolated from snails, this study aimed to investigate the protective effect of Cornu aspersum (Müller, 1774) mucus on ethanol-induced GUs. Male albino mice were divided into Control, Ethanol, Mucus + Ethanol and Mucus + Omeprazole treated groups. The GUs were induced by administration of 96% ethanol (10 mL/kg, per os). One hour before ulcer induction, the mice of Mucus + Ethanol group were pretreated with mucus (20 mg/kg, per os), and the mice of Mucus + Omeprazole group were pretreated with omeprazole (20 mg/kg, per os). Ethanol administration caused grave lesions of gastric mucosa and a significant decrease of glutathione (GSH) and superoxide dismutase (SOD), catalase, and glutathione reductase (GR) activities. In the animals with mucus or omeprazole pre-administration compared to the Ethanol group, the following were observed: only a small number of hemorrhagic fields, significantly reduced GU index with calculated 73% protection by mucus and 78% protection by omeprazole, and significant recovery of mucosal GSH and SOD and GR activities. In addition, the mucus inhibited Helicobacter pylori growth. Thus, the protective effect of C. aspersum mucus on both gastric mucosa and gastric antioxidant potential in ethanol-induced GU model suggests that it may serve as a good tool for prevention of this disease.
摘要：
如今,已经观察到对各种疾病具有预防或治疗潜力的天然化合物的兴趣增加。鉴于氧化应激参与胃溃疡（GU）的发病机制和广泛的生物活性化合物从蜗牛分离，本研究旨在研究玉米的保护作用(Müller，1774)乙醇诱导的GU上的粘液。雄性白化小鼠分为对照组，乙醇,粘液+乙醇和粘液+奥美拉唑治疗组。通过施用96%乙醇(10mL/kg，每个操作系统)。溃疡诱导前一小时，粘液+乙醇组小鼠用粘液预处理(20mg/kg，每个操作系统)，粘液+奥美拉唑组小鼠用奥美拉唑预处理(20mg/kg，每个操作系统)。乙醇给药引起胃粘膜严重病变，谷胱甘肽（GSH）和超氧化物歧化酶（SOD）显着降低，过氧化氢酶,和谷胱甘肽还原酶（GR）活性。与乙醇组相比，在有粘液或奥美拉唑预先给药的动物中，观察到以下情况:只有少数出血场，显著降低GU指数，计算出73%的粘液保护和78%的奥美拉唑保护，粘膜GSH、SOD和GR活性显著恢复。此外,粘液抑制了幽门螺杆菌的生长。因此，在乙醇诱导的GU模型中,刺槐粘液对胃粘膜和胃抗氧化潜能的保护作用表明,它可能是预防这种疾病的良好工具。
