PDF(Pubmed)
Abstract：
OBJECTIVE: The etiology of exocrine pancreatic cancer (EPC) remains unknown except for family history and smoking. Despite recent medical advances, rates of pancreatic cancer incidence and mortality are increasing. Although existing evidence suggests a potentially causal relationship between environmental chemical exposures and pancreatic cancer, whether residential exposure impacts pancreatic cancer rates remains unknown.
METHODS: The authors identified 28 941 patients diagnosed with exocrine pancreatic cancer in New York State exclusive of New York City for the years 1996-2013. Descriptive statistics and negative binomial regression were used in this ecological study to compare pancreatic cancer hospitalization rates among patients who lived in zip codes with hazardous waste sites (HWSs) containing persistent organic pollutants (POPs) and volatile organic pollutants (VOCs) compared with clean zip codes with no identified hazardous waste sites. The authors assessed the effect of selected known and suspected human carcinogens on the EPC hospitalization rates by subgroup analyses.
RESULTS: Compared with the clean sites, the pancreatic cancer hospital discharge rate in the \"VOCs without POPs\" and \"VOCs and POPs\" sites, after adjustment for potential confounders were 1.06 (95% CI: 1.03-1.09) and 1.05 (95% CI: 1.01-1.08), respectively. In the analysis by specific chemicals, rate ratios (RR) for the benzene (RR = 1.12) and ethylbenzene (RR = 1.34) in the non-chlorinated VOCs group, trichloroethylene (RR = 1.07) and tetrachloroethylene (RR = 1.11) in the chlorinated VOCs group, chlorinated pesticides (RR = 1.11) and PCBs (RR = 1.05) in the POPs groups were statistically significant (p-values <0.05) compared with clean sites.
CONCLUSIONS: Compared with the clean sites, the pancreatic cancer hospital discharge rate in the \"VOCs without POPs\" and \"VOCs and POPs\" sites, after adjustment for potential confounders were 1.06 (95% CI: 1.03-1.09) and 1.05 (95% CI: 1.01-1.08), respectively. In the analysis by specific chemicals, rate ratios (RR) for the benzene (RR = 1.12) and ethylbenzene (RR = 1.34) in the non-chlorinated VOCs group, trichloroethylene (RR = 1.07) and tetrachloroethylene (RR = 1.11) in the chlorinated VOCs group, chlorinated pesticides (RR = 1.11) and PCBs (RR = 1.05) in the POPs groups were statistically significant (p-values <0.05) compared with clean sites. Int J Occup Med Environ Health. 2022;35(4):459-71.
METHODS: The authors identified 28 941 patients diagnosed with exocrine pancreatic cancer in New York State exclusive of New York City for the years 1996-2013. Descriptive statistics and negative binomial regression were used in this ecological study to compare pancreatic cancer hospitalization rates among patients who lived in zip codes with hazardous waste sites (HWSs) containing persistent organic pollutants (POPs) and volatile organic pollutants (VOCs) compared with clean zip codes with no identified hazardous waste sites. The authors assessed the effect of selected known and suspected human carcinogens on the EPC hospitalization rates by subgroup analyses.
RESULTS: Compared with the clean sites, the pancreatic cancer hospital discharge rate in the \"VOCs without POPs\" and \"VOCs and POPs\" sites, after adjustment for potential confounders were 1.06 (95% CI: 1.03-1.09) and 1.05 (95% CI: 1.01-1.08), respectively. In the analysis by specific chemicals, rate ratios (RR) for the benzene (RR = 1.12) and ethylbenzene (RR = 1.34) in the non-chlorinated VOCs group, trichloroethylene (RR = 1.07) and tetrachloroethylene (RR = 1.11) in the chlorinated VOCs group, chlorinated pesticides (RR = 1.11) and PCBs (RR = 1.05) in the POPs groups were statistically significant (p-values <0.05) compared with clean sites.
CONCLUSIONS: Compared with the clean sites, the pancreatic cancer hospital discharge rate in the \"VOCs without POPs\" and \"VOCs and POPs\" sites, after adjustment for potential confounders were 1.06 (95% CI: 1.03-1.09) and 1.05 (95% CI: 1.01-1.08), respectively. In the analysis by specific chemicals, rate ratios (RR) for the benzene (RR = 1.12) and ethylbenzene (RR = 1.34) in the non-chlorinated VOCs group, trichloroethylene (RR = 1.07) and tetrachloroethylene (RR = 1.11) in the chlorinated VOCs group, chlorinated pesticides (RR = 1.11) and PCBs (RR = 1.05) in the POPs groups were statistically significant (p-values <0.05) compared with clean sites. Int J Occup Med Environ Health. 2022;35(4):459-71.
摘要：
目的：除家族史和吸烟外，外分泌型胰腺癌（EPC）的病因尚不清楚。尽管最近的医学进步，胰腺癌的发病率和死亡率正在上升。尽管现有证据表明环境化学物质暴露与胰腺癌之间存在潜在的因果关系，住宅暴露是否会影响胰腺癌的发病率尚不清楚.
方法：作者在1996-2013年间确定了纽约州不包括纽约市的28941例诊断为外分泌胰腺癌的患者。在这项生态研究中使用了描述性统计和负二项回归，以比较居住在含有持久性有机污染物（POPs）和挥发性有机污染物（VOCs）的邮政编码危险废物场所（HWS）的患者中的胰腺癌住院率。作者通过亚组分析评估了选定的已知和可疑人类致癌物对EPC住院率的影响。
结果：与干净的场地相比，胰腺癌医院出院率在“无POPs的VOCs”和“VOCs和POPs”网站，在对潜在混杂因素进行调整后，分别为1.06(95%CI：1.03-1.09)和1.05(95%CI：1.01-1.08)，分别。在特定化学物质的分析中，非氯化VOCs组中苯(RR=1.12)和乙苯(RR=1.34)的速率比(RR)，氯化VOCs组中的三氯乙烯（RR=1.07）和四氯乙烯（RR=1.11），与清洁场所相比，POPs组的氯化农药（RR=1.11）和多氯联苯（RR=1.05）具有统计学意义（p值<0.05）。
结论：与清洁场所相比，胰腺癌医院出院率在“无POPs的VOCs”和“VOCs和POPs”网站，在对潜在混杂因素进行调整后，分别为1.06(95%CI：1.03-1.09)和1.05(95%CI：1.01-1.08)，分别。在特定化学物质的分析中，非氯化VOCs组中苯(RR=1.12)和乙苯(RR=1.34)的速率比(RR)，氯化VOCs组中的三氯乙烯（RR=1.07）和四氯乙烯（RR=1.11），与清洁场所相比，POPs组的氯化农药（RR=1.11）和多氯联苯（RR=1.05）具有统计学意义（p值<0.05）。IntJOccupMedEnvironHealth。2022年；35（4）：459-71。
方法：作者在1996-2013年间确定了纽约州不包括纽约市的28941例诊断为外分泌胰腺癌的患者。在这项生态研究中使用了描述性统计和负二项回归，以比较居住在含有持久性有机污染物（POPs）和挥发性有机污染物（VOCs）的邮政编码危险废物场所（HWS）的患者中的胰腺癌住院率。作者通过亚组分析评估了选定的已知和可疑人类致癌物对EPC住院率的影响。
结果：与干净的场地相比，胰腺癌医院出院率在“无POPs的VOCs”和“VOCs和POPs”网站，在对潜在混杂因素进行调整后，分别为1.06(95%CI：1.03-1.09)和1.05(95%CI：1.01-1.08)，分别。在特定化学物质的分析中，非氯化VOCs组中苯(RR=1.12)和乙苯(RR=1.34)的速率比(RR)，氯化VOCs组中的三氯乙烯（RR=1.07）和四氯乙烯（RR=1.11），与清洁场所相比，POPs组的氯化农药（RR=1.11）和多氯联苯（RR=1.05）具有统计学意义（p值<0.05）。
结论：与清洁场所相比，胰腺癌医院出院率在“无POPs的VOCs”和“VOCs和POPs”网站，在对潜在混杂因素进行调整后，分别为1.06(95%CI：1.03-1.09)和1.05(95%CI：1.01-1.08)，分别。在特定化学物质的分析中，非氯化VOCs组中苯(RR=1.12)和乙苯(RR=1.34)的速率比(RR)，氯化VOCs组中的三氯乙烯（RR=1.07）和四氯乙烯（RR=1.11），与清洁场所相比，POPs组的氯化农药（RR=1.11）和多氯联苯（RR=1.05）具有统计学意义（p值<0.05）。IntJOccupMedEnvironHealth。2022年；35（4）：459-71。
