PDF(Pubmed)
Abstract：
Organoids are 3D structures grown from pluripotent stem cells derived from human tissue and serve as in vitro miniature models of human organs. Organoids are expected to revolutionize biomedical research and clinical care. However, organoids are not seen as morally neutral. For instance, tissue donors may perceive enduring personal connections with their organoids, setting higher bars for informed consent and patient participation. Also, several organoid sub-types, e.g., brain organoids and human-animal chimeric organoids, have raised controversy. This systematic review provides an overview of ethical discussions as conducted in the scientific literature on organoids. The review covers both research and clinical applications of organoid technology and discusses the topics informed consent, commercialization, personalized medicine, transplantation, brain organoids, chimeras, and gastruloids. It shows that further ethical research is needed especially on organoid transplantation, to help ensure the responsible development and clinical implementation of this technology in this field.
摘要：
类器官是由源自人体组织的多能干细胞生长而成的3D结构，可作为人体器官的体外微型模型。类器官有望彻底改变生物医学研究和临床护理。然而,类器官不被视为道德中立。例如,组织捐献者可能会感觉到与他们的类器官有持久的个人联系，为知情同意和患者参与设置更高的门槛。此外，几种类器官亚型，例如，脑类器官和人-动物嵌合类器官，引发了争议。本系统综述概述了有关类器官的科学文献中进行的伦理讨论。该综述涵盖类器官技术的研究和临床应用，并讨论了知情同意的主题，商业化，个性化医疗，移植,大脑类器官，嵌合体,和gastruloids。它表明需要进一步的伦理研究，特别是在类器官移植方面，以帮助确保该技术在该领域的负责任的开发和临床实施。
