Abstract：
Ovarian immature teratoma is a rare subtype of germ cell tumour that can be pure or associated with non-teratomatous germ cell tumour elements and is graded based on extent of the immature neuroectodermal component. Immature teratoma (IT) can also be associated with somatic differentiation in the form of sarcoma, carcinoma, or extensive immature neuroectodermal elements and may produce low levels of serum alpha-fetoprotein. Variable interpretation of these issues underlies diagnostic and management dilemmas, resulting in substantial practice differences between paediatric and adult women with IT. The Malignant Germ Cell International Consortium (MaGIC) convened oncologists, surgeons, and pathologists to address the following crucial clinicopathologic issues related to IT: (1) grading of IT, (2) definition and significance of \'microscopic\' yolk sac tumour, (3) transformation to a somatic malignancy, and (4) interpretation of serum tumour biomarkers. This review highlights the discussion, conclusions, and suggested next steps from this clinicopathologic conference.
摘要：
卵巢未成熟畸胎瘤是生殖细胞肿瘤的一种罕见亚型，可以是纯的或与非畸胎性生殖细胞肿瘤成分相关，并根据未成熟神经外胚层成分的程度进行分级。未成熟畸胎瘤（IT）也可以与肉瘤形式的体细胞分化有关，癌,或广泛的未成熟神经外胚层成分，并可能产生低水平的血清甲胎蛋白。对这些问题的可变解释是诊断和管理困境的基础，导致儿科和成年女性IT之间的实践差异很大。恶性生殖细胞国际联合会（MaGIC）召集了肿瘤学家，外科医生,和病理学家解决以下与IT相关的关键临床病理问题：（1）IT分级，(2)“微观”卵黄囊瘤的定义和意义，(3)转化为躯体恶性肿瘤，(4)血清肿瘤生物标志物的解释。这篇评论突出了讨论，结论,并从这次临床病理会议中提出了下一步措施。
