PDF(Pubmed)
Abstract：
UNASSIGNED: Opioid-dependent patients undergoing opioid substitution therapy (OST) consume alcohol in a hazardous pattern which adversely affects their treatment outcome. This study aims to measure alcohol biomarkers to screen for secondary alcohol use in OST patients.
UNASSIGNED: A pilot study was planned to measure alcohol biomarkers (AST, ALT, GGT, and CDT) to assess alcohol use in OST patients from three community clinics. The biomarkers were categorized based on the reported frequency of alcohol use. The association of the biomarkers with the frequency of alcohol consumption was determined using the post hoc (Mann-Whitney) test.
UNASSIGNED: Forty-five patients with a mean (SD) age of 37.04 (10.7) years were included in the study. Alcohol intake was reported in daily, weekly, and monthly patterns by 22, 63, and 16% of the patients, respectively. High levels of ALT, GGT, and CDT were measured in patients with daily use of alcohol. Serum CDT levels significantly differentiate daily and weekly use from monthly consumption of alcohol.
UNASSIGNED: Alcohol biomarkers significantly predict the pattern of alcohol use among OST patients. These results can be prudent in low-resource community clinics to improve the overall outcomes of OST in India.
UNASSIGNED: A pilot study was planned to measure alcohol biomarkers (AST, ALT, GGT, and CDT) to assess alcohol use in OST patients from three community clinics. The biomarkers were categorized based on the reported frequency of alcohol use. The association of the biomarkers with the frequency of alcohol consumption was determined using the post hoc (Mann-Whitney) test.
UNASSIGNED: Forty-five patients with a mean (SD) age of 37.04 (10.7) years were included in the study. Alcohol intake was reported in daily, weekly, and monthly patterns by 22, 63, and 16% of the patients, respectively. High levels of ALT, GGT, and CDT were measured in patients with daily use of alcohol. Serum CDT levels significantly differentiate daily and weekly use from monthly consumption of alcohol.
UNASSIGNED: Alcohol biomarkers significantly predict the pattern of alcohol use among OST patients. These results can be prudent in low-resource community clinics to improve the overall outcomes of OST in India.
摘要：
■接受阿片类药物替代疗法（OST）的阿片类药物依赖患者以危险的方式饮酒，这对他们的治疗结果产生不利影响。这项研究旨在测量酒精生物标志物，以筛查OST患者的二次酒精使用。
■计划进行一项初步研究以测量酒精生物标志物（AST，ALT,GGT,和CDT）评估来自三个社区诊所的OST患者的酒精使用情况。根据报告的酒精使用频率对生物标志物进行分类。使用事后(Mann-Whitney)测试确定生物标志物与饮酒频率的关联。
■45名平均年龄（SD）为37.04（10.7）岁的患者被纳入研究。每天报告酒精摄入量，每周,以及22％，63％和16％的患者的月模式，分别。高水平的ALT,GGT,并对每日饮酒患者进行CDT测定。血清CDT水平显着区分每日和每周使用与每月饮酒。
■酒精生物标志物可显著预测OST患者的饮酒模式。这些结果在资源匮乏的社区诊所中可以谨慎，以改善印度OST的整体结果。
■计划进行一项初步研究以测量酒精生物标志物（AST，ALT,GGT,和CDT）评估来自三个社区诊所的OST患者的酒精使用情况。根据报告的酒精使用频率对生物标志物进行分类。使用事后(Mann-Whitney)测试确定生物标志物与饮酒频率的关联。
■45名平均年龄（SD）为37.04（10.7）岁的患者被纳入研究。每天报告酒精摄入量，每周,以及22％，63％和16％的患者的月模式，分别。高水平的ALT,GGT,并对每日饮酒患者进行CDT测定。血清CDT水平显着区分每日和每周使用与每月饮酒。
■酒精生物标志物可显著预测OST患者的饮酒模式。这些结果在资源匮乏的社区诊所中可以谨慎，以改善印度OST的整体结果。
