脂肪细胞 HIF - 1 α 的破坏通过抑制神经酰胺的产生改善动脉粥样硬化。
关键词: ACER2/3, alkaline ceramidase 2/3 APOE, apolipoprotein E ARNT, aryl hydrocarbon nuclear translocator Adipocyte Atherosclerosis CCL5, chemokine (C–C motif) ligand 5 CERS2/4/5/6, ceramide synthase 2/4/5/6 CXCL1, chemokine (C–X–C motif) ligand 1 protein Ceramide ChIP, chromatin immunoprecipitation Cholesterol CoCl2, cobalt(Ⅱ) chloride DEGS1, delta(4)-desaturase, sphingolipid 1 EIF5, eukaryotic translation initiation factor 5 GFP, green fluorescent protein HDL, high-density lipoprotein HIF-1α HIF-1α/2α/3α, hypoxia-inducible factor 1 alpha/2 alpha/3 alpha HREs, HIF-response elements IL-6/1β, interleukin-6/1β Inflammatory responses LDL, low-density lipoprotein MAC-2, lectin, galactose binding, soluble 3 MCP-1, monocyte chemoattractant protein-1 PC, phosphatidylcholine PLS-DA, partial least squares discriminant analysis PX-478 SGMS1, sphingomyelin synthase 1 SM, sphingomyelin SMPD1/2/3/4, sphingomyelin phosphodiesterase 1/2/3/4 SMPD3 SMase, sphingomyelinase SPTLC1/2/3, serine palmitoyltransferase long chain base subunit 1/2/3 TNF-α, tumor necrosis factor alpha VEGF, vascular endothelial growth factor VIP, variable importance for the projection VLDL, very low-density lipoprotein eWAT, epididymal white adipose tissue ACER2/3, alkaline ceramidase 2/3 APOE, apolipoprotein E ARNT, aryl hydrocarbon nuclear translocator Adipocyte Atherosclerosis CCL5, chemokine (C–C motif) ligand 5 CERS2/4/5/6, ceramide synthase 2/4/5/6 CXCL1, chemokine (C–X–C motif) ligand 1 protein Ceramide ChIP, chromatin immunoprecipitation Cholesterol CoCl2, cobalt(Ⅱ) chloride DEGS1, delta(4)-desaturase, sphingolipid 1 EIF5, eukaryotic translation initiation factor 5 GFP, green fluorescent protein HDL, high-density lipoprotein HIF-1α HIF-1α/2α/3α, hypoxia-inducible factor 1 alpha/2 alpha/3 alpha HREs, HIF-response elements IL-6/1β, interleukin-6/1β Inflammatory responses LDL, low-density lipoprotein MAC-2, lectin, galactose binding, soluble 3 MCP-1, monocyte chemoattractant protein-1 PC, phosphatidylcholine PLS-DA, partial least squares discriminant analysis PX-478 SGMS1, sphingomyelin synthase 1 SM, sphingomyelin SMPD1/2/3/4, sphingomyelin phosphodiesterase 1/2/3/4 SMPD3 SMase, sphingomyelinase SPTLC1/2/3, serine palmitoyltransferase long chain base subunit 1/2/3 TNF-α, tumor necrosis factor alpha VEGF, vascular endothelial growth factor VIP, variable importance for the projection VLDL, very low-density lipoprotein eWAT, epididymal white adipose tissue
来 源:
DOI:10.1016/j.apsb.2021.10.001
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